BNIP3 cdna clone
BNIP3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
Uniprot Description
BNIP3: Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family.
Protein type: Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: cytoplasm; dendrite; endoplasmic reticulum; integral to mitochondrial outer membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus
Molecular Function: GTPase binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: apoptosis; cell death; defense response to virus; induction of apoptosis by granzyme; mitochondrial fragmentation during apoptosis; negative regulation of apoptosis; negative regulation of membrane potential; neuron apoptosis; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of programmed cell death; positive regulation of protein complex disassembly; regulation of mitochondrial membrane permeability; response to hypoxia
Research Articles on BNIP3
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Product Notes
The BNIP3 bnip3 (Catalog #AAA1271761) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtcgcaga acggagcgcc cgggatgcag gaggagagcc tgcagggctc ctgggtagaa ctgcacttca gcaataatgg gaacgggggc agcgttccag cctcggtttc tatttataat ggagacatgg aaaaaatact gctggacgca cagcatgagt ctggacggag tagctccaag agctctcact gtgacagccc acctcgctcg cagacaccac aagataccaa cagagcttct gaaacagata cccatagcat tggagagaaa aacagctcac agtctgagga agatgatatt gaaagaagga aagaagttga aagcatcttg aagaaaaact cagattggat atgggattgg tcaagtcggc cggaaaatat tccccccaag gagttcctct ttaaacaccc gaagcgcacg gccaccctca gcatgaggaa cacgagcgtc atgaagaaag ggggcatatt ctctgcagaa tttctgaaag ttttccttcc atctctgctg ctctctcatt tgctggccat cggattgggg atctatattg gaaggcgtct gacaacctcc accagcacct tttga. It is sometimes possible for the material contained within the vial of "BNIP3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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