EPHB1 cdna clone
EPHB1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
Uniprot Description
EphB1: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known.
Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; TK group; Eph family
Chromosomal Location of Human Ortholog: 3q21-q23
Cellular Component: cytosol; early endosome membrane; extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; transmembrane-ephrin receptor activity
Biological Process: angiogenesis; axon guidance; cell-substrate adhesion; central nervous system projection neuron axonogenesis; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; establishment of cell polarity; neurogenesis; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of JNK cascade; retinal ganglion cell axon guidance
Research Articles on EPHB1
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Product Notes
The EPHB1 ephb1 (Catalog #AAA1271308) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCCTGG ATTATCTACT ACTGCTCCTC CTGGCATCCG CAGTGGCTGC GATGGAAGAA ACGTTAATGG ACACCAGAAC GGCTACTGCA GAGCTGGGCT GGACGGCCAA TCCTGCGTCC GGGTGGGAAG AAGTCAGTGG CTACGATGAA AACCTGAACA CCATCCGCAC CTACCAGGTG TGCAATGTCT TCGAGCCCAA CCAGAACAAT TGGCTGCTCA CCACCTTCAT CAACCGGCGG GGGGCCCATC GCATCTACAC AGAGATGCGC TTCACTGTGA GAGACTGCAG CAGCCTCCCT AATGTCCCAG GATCCTGCAA GGAGACCTTC AACTTGTATT ACTATGAGAC TGACTCTGTC ATTGCCACCA AGAAGTCAGC CTTCTGGTCT GAGGCCCCCT ACCTCAAAGT AGACACCATT GCTGCAGATG AGAGCTTCTC CCAGGTGGAC TTTGGGGGAA GGCTGATGAA GGTAAACACA GAAGTCAGGA GCTTTGGGCC TCTTACTCGG AATGGTTTTT ACCTCGCTTT TCAGGATTAT GGAGCCTGTA TGTCTCTTCT TTCTGTCCGT GTCTTCTTCA AAAAGTGTCC CAGCATTGTG CAAAATTTTG CAGTGTTTCC AGAGACTATG ACAGGGGCAG AGAGCACATC TCTGGTGATT GCTCGGGGCA CATGCATCCC CAACGCAGAG GAAGTGGACG TGCCCATCAA ACTCTACTGC AACGGGGATG GGGAATGGAT GGTGCCTATT GGGCGATGCA CCTGCAAGCC TGGCTATGAG CCTGAGAACA GCGTGGCATG CAAGGCTTGC CCTGCAGGGA CATTCAAGGC CAGCCAGGAA GCTGAAGGCT GCTCCCACTG CCCCTCCAAC AGCCGCTCCC CTGCAGAGGC GTCTCCCATC TGCACCTGTC GGACCGGTTA TTACCGAGCG GACTTTGACC CTCCAGAAGT GGCATGCACT AGCGTCCCAT CAGGTCCCCG CAATGTTATC TCCATCGTCA ATGAGACGTC CATCATTCTG GAGTGGCACC CTCCAAGGGA GACAGGTGGG CGGGATGATG TGACCTACAA CATCATCTGC AAAAAGTGCC GGGCAGACCG CCGGAGCTGC TCCCGCTGTG ACGACAATGT GGAGTTTGTG CCCAGGCAGC TGGGCCTGAC GGAGTGCCGC GTCTCCATCA GCAGCCTGTG GGCCCACACC CCCTACACCT TTGACATCCA GGCCATCAAT GGAGTCTCCA GCAAGAGTCC CTTCCCCCCA CAGCACGTCT CTGTCAACAT CACCACAAAC CAAGCCGCCC CCTCCACCGT TCCCATCATG CACCAAGTCA GTGCCACTAT GAGGAGCATC ACCTTGTCAT GGCCACAGCC GGAGCAGCCC AATGGCATCA TCCTGGACTA TGAGATCCGG TACTATGAGA AGGAACACAA TGAGTTCAAC TCCTCCATGG CCAGGAGTCA GACCAACACA GCAAGGATTG ATGGGCTGCG GCCTGGCATG GTATATGTGG TACAGGTGCG TGCCCGCACT GTTGCTGGCT ACGGCAAGTT CAGTGGCAAG ATGTGCTTCC AGACTCTGAC TGACGATGAT TACAAGTCAG AGCTGAGGGA GCAGCTGCCC CTGATTGCTG GCTCGGCAGC GGCCGGGGTC GTGTTCGTTG TGTCCTTGGT GGCCATCTCT ATCGTCTGTA GCAGGAAACG GGCTTATAGC AAAGAGGCTG TGTACAGCGA TAAGCTCCAG CATTACAGCA CAGGCCGAGG CTCCCCAGGG ATGAAGATCT ACATTGACCC CTTCACTTAT GAGGATCCCA ACGAAGCTGT CCGGGAGTTT GCCAAGGAGA TTGATGTATC TTTTGTGAAA ATTGAAGAGG TCATCGGAGC AGGGGAGTTT GGAGAAGTGT ACAAGGGGCG TTTGAAACTG CCAGGCAAGA GGGAAATCTA CGTGGCCATC AAGACCCTGA AGGCAGGGTA CTCGGAGAAG CAGCGTCGGG ACTTTCTGAG TGAGGCGAGC ATCATGGGCC AGTTCGACCA TCCTAACATC ATTCGCCTGG AGGGTGTGGT CACCAAGAGT CGGCCTGTCA TGATCATCAC AGAGTTCATG GAGAATGGTG CATTGGATTC TTTCCTCAGG CAAAATGACG GGCAGTTCAC CGTGATCCAG CTTGTGGGTA TGCTCAGGGG CATCGCTGCT GGCATGAAGT ACCTGGCTGA GATGAATTAT GTGCATCGGG ACCTGGCTGC TAGGAACATT CTGCTCAACA GTAACCTGGT GTGCAAGGTG TCCGACTTTG GCCTCTCCCG CTACCTCCAG GATGACACCT CAGATCCCAC CTACACCAGC TCCTTGGGAG GGAAGATCCC TGTGAGATGG ACAGCTCCAG AGGCCATCGC CTACCGCAAG TTCACTTCAG CCAGCGACGT TTGGAGCTAT GGGATCGTCA TGTGGGAAGT CATGTCATTT GGAGAGAGAC CCTATTGGGA TATGTCCAAC CAAGATGTCA TCAATGCCAT CGAGCAGGAC TACCGGCTGC CCCCACCCAT GGACTGTCCA GCTGCTCTAC ACCAGCTCAT GCTGGACTGT TGGCAGAAGG ACCGGAACAG CCGGCCCCGG TTTGCGGAGA TTGTCAACAC CCTAGATAAG ATGATCCGGA ACCCGGCAAG TCTCAAGACT GTGGCAACCA TCACCGCCGT GCCTTCCCAG CCCCTGCTCG ACCGCTCCAT CCCAGACTTC ACGGCCTTTA CCACCGTGGA TGACTGGCTC AGCGCCATCA AAATGGTCCA GTACAGGGAC AGCTTCCTCA CTGCTGGCTT CACCTCCCTC CAGCTGGTCA CCCAGATGAC ATCAGAAGAC CTCCTGAGAA TAGGCATCAC CTTGGCAGGC CATCAGAAGA AGATCCTGAA CAGCATTCAT TCTATGAGGG TCCAGATAAG TCAGTCACCA ACGGCAATGG CATGA. It is sometimes possible for the material contained within the vial of "EPHB1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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