RCHY1 cdna clone
RCHY1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Uniprot Description
RCHY1: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and p27Kip1. Preferentially acts on tetrameric p53/TP53. Contributes to the regulation of p27Kip1 and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, p27Kip1, COPE, UBE2D2 and GORAB/NTKLBP1. Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-; Nuclear receptor co-regulator; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: cytoplasm; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: p53 binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Research Articles on RCHY1
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Product Notes
The RCHY1 rchy1 (Catalog #AAA1269884) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggcga cggcccggga agatggcgcc agcggtcaag agcgaggtca gcggggctgc gagcactatg acagaggatg tctcctaaag gcaccttgct gtgacaagct ttatacttgc cgcttgtgtc atgataacaa tgaagatcat caactagatc gctttaaagt gaaggaagtg cagtgcataa actgtgaaaa aattcaacat gcccaacaga cttgtgaaga atgtagcaca ttgtttggag aatattattg cgatatatgc catttgtttg acaaagataa gaagcagtat cactgtgaaa actgtggaat ttgtaggatt ggtccaaagg aagatttttt ccattgtttg aaatgtaact tatgcctagc tatgaatctt caaggaagac acaagtgtat tgaaaatgtg tcccgacaga attgtccaat atgtttggag gacattcaca catcccgtgt tgttgctcat gtcttgccat gtggacatct tttacatagg taa. It is sometimes possible for the material contained within the vial of "RCHY1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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