Rabbit CCR4 Polyclonal Antibody | anti-CCR4 antibody

Rabbit Polyclonal to Human CCR4

Cat. Num. AAA241421

• Gene Names: CCR4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CCR4; Polyclonal Antibody; Rabbit Polyclonal to Human CCR4; Anti-CCR4 Antibody (C-Terminus) IHC-plus; C-C chemokine receptor type 4; CD194; CD194 antigen; C-C CKR-4; Chemr13; CKR-4; CC chemokine receptor 4; CC-CKR-4; CCR-4; HGCN:14099; C-c chemokine receptor 4; Chemokine (C-C) receptor 4; CKR4; CMKBR4; K5-5; Human CCR4; anti-CCR4 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CCR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 360

• Applicable Applications for anti-CCR4 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA, IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human CCR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Elephant (94%); Hamster (88%); Dog, Panda, Horse (81%).
• Immunogen Type: Synthetic peptide
• Immunogen: CCR4 antibody was raised against synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human CCR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Elephant (94%); Hamster (88%); Dog, Panda, Horse (81%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CCR4 antibody

CCR4, a Chemokine Receptor, mediates inflammatory responses and HIV-1 infections. It binds beta-family chemokines (CC motif) such as TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derived chemokine).

Product Categories/Family for anti-CCR4 antibody

Family: GPCR; Subfamily: Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 5031627
• NCBI GeneID: 1233
• NCBI Accession #: NP_005499.1
• NCBI GenBank Nucleotide #: NM_005508.4
• UniProt Accession #: P51679; Q9ULY6; Q9ULY7
• Molecular Weight: 41,403 Da
• NCBI Official Full Name: C-C chemokine receptor type 4
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 4
• NCBI Official Symbol: CCR4
• NCBI Official Synonym Symbols: CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099
• NCBI Protein Information: C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4
• UniProt Protein Name: C-C chemokine receptor type 4
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR4
• UniProt Synonym Gene Names: CMKBR4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4
• UniProt Entry Name: CCR4_HUMAN

NCBI Description

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Uniprot Description

CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p24

Cellular Component: cell soma; integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: response to antibiotic; G-protein coupled receptor protein signaling pathway; response to radiation; elevation of cytosolic calcium ion concentration; positive regulation of positive chemotaxis; response to bacterium; neuron migration; immune response; inflammatory response; chemotaxis; tolerance induction