ARHGEF1 cdna clone

ARHGEF1 cDNA Clone

Gene Names

ARHGEF1; LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF

Synonyms

ARHGEF1; ARHGEF1 cDNA Clone; ARHGEF1 cdna clone

Ordering
Cat. Num. AAA1269840 For Research Use Only!

Sequence

atggaagacttcgcccgaggggcggcctccccaggcccctcccggcctggcctggttcccgtcagcatcatcggggctgaggatgaggattttgagaacgagctggagacaaactcagaagagcaaaacagccagttccagagcctggagcaggtgaagcggcgcccagcccacctcatggccctcctgcagcacgtggccctgcagtttgagccaggacccctggttctccgggtgccggtccctcccaacgtcgcctttgaacttgaccgcactagggctgacctcatctccgaggatgtccagcggcggttcgtgcaggaggtggtgcaaagccagcaggtagccgtgggccggcagctggaggacttccgttccaagcggctcatgggcatgacgccctgggagcaggagctggcccagctggaggcttgggttgggcgggaccgagccagctacgaggcccgggagcggcacgtggcggagcggctgctcatgcacctggaggagatgcaacataccatctctaccgacgaagaaaagagtgctgccgtggtcaacgccattggcctgtacatgcgccaccttggggtgcggaccaagagtggagacaagaagtcggggaggaacttcttccggaaaaaggtgatggggaaccggcggtcggacgagcctgccaagaccaagaaggggctgagcagcatcctggatgccgcccgctggaaccggggagagccccaggttccagattttcgacacctcaaagcagaggttgatgccgagaagccaggtgctacagaccggaagggaggcgtggggatgccctctcgggaccggaatatcggggctcctgggcaggacacccctggagtctctctgcaccctctgtccctggacagcccagaccgggaaccaggtgctgacgcccccctggagctgggggactcatccccgcagggcccaatgagcctggagtccttggcgcccccagagagtaccgacgagggggccgaaaccgagagccccgagcctggagatgagggggagccggggcggtcgggactggagcttgaaccagaagagcctcccggctggcgggaactcgtccccccagacaccctgcacagcctgcccaagagccaggtgaagcggcaggaggtcatcagcgagctgctggtgacagaggcggcccacgtgcgcatgctgcgggtgctgcacgacctcttcttccagcccatggcagaatgcctgttcttccccttggaggagctgcagaacatcttccccagcctggacgagctcatcgaggtgcattccctgttcctcgatcgcctgatgaagcggaggcaggagagtggctacctcatcgaggagatcggagacgtgctgctggcccggtttgatggtgctgagggctcctggttccagaaaatctcctcccgcttctgcagccgccagtcatttgccttagagcagctcaaagccaagcaacgcaaggaccctcggttctgtgccttcgtgcaggaagctgagagccgcccgcggtgccgccgcctgcagctgaaggacatgatccccacggagatgcagcggctgaccaagtaccccctgctcctgcagagcatcgggcagaacacagaagagcccacagaacgggagaaagtggagctggcagccgagtgctgccgggaaattctacaccacgtcaaccaagccgtgcgtgacatggaggacctgctgaggctcaaggactatcagcggcgcctggacttgtcccaccttcggcagagcagcgaccctatgctgagcgagttcaagaacctggacatcaccaagaagaaattggtccacgagggcccactgacgtggcgggtgactaaggacaaggcagtggaggtgcatgtgctgctgctggacgacctgctgctgctgctccagcgccaggacgagcggctgctgctcaagtcccatagccggacactgacgcccacgcccgatggcaagaccatgctgcggcccgtgctgcggctcacctccgccatgacccgcgaggtggccaccgatcacaaagccttctacgtcctttttacctgggaccaggaggcccagatatacgagctggtggcacagactgtgtcggagcggaaaaactggtgtgctctcatcactgagactgccggatccctgaaagtccctgcccctgcctctcgccctaagccccggcccagcccgagcagcacccgagaacccctcctcagcagctctgagaacggcaatggtggccgagagacgtctccagctgatgcccggaccgagagaatcctcagtgacctcctgcccttctgcagaccaggccccgagggccagctcgctgccacggcccttcggaaagtgctgtccctgaagcagcttctgtttccggcggaggaagacaatggggcggggcctcctcgagatggggatggggtcccagggggcggccccctgagcccagcacggacccaggaaatccaggagaacctgctcagcttggaggagaccatgaagcagctggaggagttggaggaggaattttgccgcctgagacccctcctgtctcagcttggggggaactctgtcccccagcctggctgcacttga

Sequence Length

2640

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

33877654

NCBI GeneID

9138

Molecular Weight

105,854 Da

NCBI Official Full Name

Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA

NCBI Official Synonym Full Names

Rho guanine nucleotide exchange factor 1

NCBI Official Symbol

ARHGEF1

NCBI Official Synonym Symbols

LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF

NCBI Protein Information

rho guanine nucleotide exchange factor 1

UniProt Protein Name

Rho guanine nucleotide exchange factor 1

Protein Family

Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF1

UniProt Synonym Gene Names

p115-RhoGEF; p115RhoGEF

UniProt Entry Name

ARHG1_HUMAN

NCBI Description

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Description

ARHGEF1: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1. Interacts with CTNNAL1. Ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: cell proliferation; negative regulation of axonogenesis; Rho protein signal transduction

Research Articles on ARHGEF1

1. contactin-1 displayed the ability to phosphorylate the RhoA activator p115 RhoGEF

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Product Notes

The ARHGEF1 arhgef1 (Catalog #AAA1269840) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggaagact tcgcccgagg ggcggcctcc ccaggcccct cccggcctgg cctggttccc gtcagcatca tcggggctga ggatgaggat tttgagaacg agctggagac aaactcagaa gagcaaaaca gccagttcca gagcctggag caggtgaagc ggcgcccagc ccacctcatg gccctcctgc agcacgtggc cctgcagttt gagccaggac ccctggttct ccgggtgccg gtccctccca acgtcgcctt tgaacttgac cgcactaggg ctgacctcat ctccgaggat gtccagcggc ggttcgtgca ggaggtggtg caaagccagc aggtagccgt gggccggcag ctggaggact tccgttccaa gcggctcatg ggcatgacgc cctgggagca ggagctggcc cagctggagg cttgggttgg gcgggaccga gccagctacg aggcccggga gcggcacgtg gcggagcggc tgctcatgca cctggaggag atgcaacata ccatctctac cgacgaagaa aagagtgctg ccgtggtcaa cgccattggc ctgtacatgc gccaccttgg ggtgcggacc aagagtggag acaagaagtc ggggaggaac ttcttccgga aaaaggtgat ggggaaccgg cggtcggacg agcctgccaa gaccaagaag gggctgagca gcatcctgga tgccgcccgc tggaaccggg gagagcccca ggttccagat tttcgacacc tcaaagcaga ggttgatgcc gagaagccag gtgctacaga ccggaaggga ggcgtgggga tgccctctcg ggaccggaat atcggggctc ctgggcagga cacccctgga gtctctctgc accctctgtc cctggacagc ccagaccggg aaccaggtgc tgacgccccc ctggagctgg gggactcatc cccgcagggc ccaatgagcc tggagtcctt ggcgccccca gagagtaccg acgagggggc cgaaaccgag agccccgagc ctggagatga gggggagccg gggcggtcgg gactggagct tgaaccagaa gagcctcccg gctggcggga actcgtcccc ccagacaccc tgcacagcct gcccaagagc caggtgaagc ggcaggaggt catcagcgag ctgctggtga cagaggcggc ccacgtgcgc atgctgcggg tgctgcacga cctcttcttc cagcccatgg cagaatgcct gttcttcccc ttggaggagc tgcagaacat cttccccagc ctggacgagc tcatcgaggt gcattccctg ttcctcgatc gcctgatgaa gcggaggcag gagagtggct acctcatcga ggagatcgga gacgtgctgc tggcccggtt tgatggtgct gagggctcct ggttccagaa aatctcctcc cgcttctgca gccgccagtc atttgcctta gagcagctca aagccaagca acgcaaggac cctcggttct gtgccttcgt gcaggaagct gagagccgcc cgcggtgccg ccgcctgcag ctgaaggaca tgatccccac ggagatgcag cggctgacca agtaccccct gctcctgcag agcatcgggc agaacacaga agagcccaca gaacgggaga aagtggagct ggcagccgag tgctgccggg aaattctaca ccacgtcaac caagccgtgc gtgacatgga ggacctgctg aggctcaagg actatcagcg gcgcctggac ttgtcccacc ttcggcagag cagcgaccct atgctgagcg agttcaagaa cctggacatc accaagaaga aattggtcca cgagggccca ctgacgtggc gggtgactaa ggacaaggca gtggaggtgc atgtgctgct gctggacgac ctgctgctgc tgctccagcg ccaggacgag cggctgctgc tcaagtccca tagccggaca ctgacgccca cgcccgatgg caagaccatg ctgcggcccg tgctgcggct cacctccgcc atgacccgcg aggtggccac cgatcacaaa gccttctacg tcctttttac ctgggaccag gaggcccaga tatacgagct ggtggcacag actgtgtcgg agcggaaaaa ctggtgtgct ctcatcactg agactgccgg atccctgaaa gtccctgccc ctgcctctcg ccctaagccc cggcccagcc cgagcagcac ccgagaaccc ctcctcagca gctctgagaa cggcaatggt ggccgagaga cgtctccagc tgatgcccgg accgagagaa tcctcagtga cctcctgccc ttctgcagac caggccccga gggccagctc gctgccacgg cccttcggaa agtgctgtcc ctgaagcagc ttctgtttcc ggcggaggaa gacaatgggg cggggcctcc tcgagatggg gatggggtcc cagggggcgg ccccctgagc ccagcacgga cccaggaaat ccaggagaac ctgctcagct tggaggagac catgaagcag ctggaggagt tggaggagga attttgccgc ctgagacccc tcctgtctca gcttgggggg aactctgtcc cccagcctgg ctgcacttga. It is sometimes possible for the material contained within the vial of "ARHGEF1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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Disclaimer

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ARHGEF1 cdna clone