NEIL2 cdna clone
NEIL2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]
Uniprot Description
NEIL2: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Belongs to the FPG family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; DNA repair, damage; Lyase; EC 4.2.99.18; Hydrolase
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: nucleoplasm
Molecular Function: DNA N-glycosylase activity; protein binding
Biological Process: depyrimidination
Research Articles on NEIL2
Similar Products
Product Notes
The NEIL2 neil2 (Catalog #AAA1269548) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgccagaag ggccgttggt gaggaaattt caccatttgg tctccccctt tgtgggtcag caggtggtca agacaggggg cagcagtaag aagctacagc ccgccagcct gcagtctctg tggctccagg acacccaggt ccatggaaag aaattattcc ttagatttga tctagatgaa gaaatggggc cccctggcag cagcccaaca ccagagcctc cacaaaaaga agtgcagaag gaaggggctg cggacccaaa gcaggtcggg gagcccagcg ggcagaagac ccttgatgga tcctcacggt ctgcagagct cgtcccccag ggcgaggatg attctgagta tttggagaga gacgcccctg caggagatgc tgggaggtgg ctgcgtgtca gctttggttt gtttggcagc gtttgggtga acgatttctc cagagccaag aaagccaaca agagggggga ctggagggac ccttccccga ggttggtcct gcactttggt ggtggtggct tcctggcatt ttataattgt cagttgtctt ggagctcttc cccggtggtc acacccacct gtgacatcct gtctgagaag ttccatcgag gacaagcctt agaagctcta ggccaggctc agcctgtctg ctatacactg ctggaccaga gatacttctc agggctaggg aacatcatta agaatgaagc cttgtacaga gctgggatcc atcccctttc tctcggttca gtcctgagtg cctcgcgtcg ggaggtcctg gtggatcacg tggtggagtt cagtacagcc tggctgcagg gcaagttcca aggcagaccg cagcacacac aggtctacca gaaagaacag tgccctgctg gccaccaggt catgaaggag gcgtttgggc ccgaagatgg gttacagagg ctcacctggt ggtgcccgca gtgccagccc cagttgtcag aggagccaga gcagtgccag ttctcctaa. It is sometimes possible for the material contained within the vial of "NEIL2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
