RAET1E cdna clone
RAET1E cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Description
RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: plasma membrane
Molecular Function: antigen binding; natural killer cell lectin-like receptor binding
Biological Process: antigen processing and presentation; natural killer cell mediated cytotoxicity; regulation of immune response; T cell mediated cytotoxicity
Research Articles on RAET1E
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Product Notes
The RAET1E raet1e (Catalog #AAA1269286) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCGAAGAA TATCCCTGAC TTCTAGCCCT GTGCGCCTTC TTTTGTTTCT GCTGTTGCTA CTAATAGCCT TGGAGATCAT GGTTGGTGGT CACTCTCTTT GCTTCAACTT CACTATAAAA TCATTGTCCA GACCTGGACA GCCCTGGTGT GAAGCGCAGG TCTTCTTGAA TAAAAATCTT TTCCTTCAGT ACAACAGTGA CAACAACATG GTCAAACCTC TGGGCCTCCT GGGGAAGAAG GTAAATGCCA CCAGCACTTG GGGAGAGTTG ACCCAAACGC TGGGAGAAGT GGGGCGAGAC CTCAGGATGC TCCTTTGTGA CATCAAACCC CAGATAAAGA CCAGTGATCC TTCCACTCTG CAAGTCGAGA TGTTTTGTCA ACATGAAGCA GAACGGTGCA CTGGTGCATC CTGGCAGTTC ACCATCAATG GAGAGAAATC CCTCCTCTTT GACGCAATGA ACATGACCTG GACAGTAATT AATCATGAAG CCAGTAAGAT CAAGGAGACA TGGAAGAAAG ACAGAGGGCT GGAAAAGTAT TTCAGGAAGC TCTCAAAGGG AGACTGCGAT CACTGGCTCA GGGAATTCTT AGGGCACTGG GAGGCAATGC CAGAACCGAC AGTGTCACCA GTAAATGCTT CAGATATCCA CTGGTCTTCT TCTAGTCTAC CAGATAGATG GATCATCCTG GGGGCATTCA TCCTGTTACT TTTAATGGGA ATTGTTCTCA TCTGTGTCTG GTGGCAAAAT GGTGAGTGGC AGGCTGGTCT CTGGCCCTTG AGGACGTCTT AG. It is sometimes possible for the material contained within the vial of "RAET1E, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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