RDH5 cdna clone
RDH5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]
Uniprot Description
RDH5: Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. Defects in RDH5 are a cause of retinitis punctata albescens (RPA); also known as fundus albipunctatus (FA). RPA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; EC 1.1.1.315
Chromosomal Location of Human Ortholog: 12q13-q14
Cellular Component: endoplasmic reticulum membrane
Molecular Function: retinol dehydrogenase activity
Biological Process: retinoid metabolic process
Disease: Fundus Albipunctatus
Research Articles on RDH5
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Product Notes
The RDH5 rdh5 (Catalog #AAA1265782) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtggctgc ctcttctgct gggtgcctta ctctgggcag tgctgtggtt gctcagggac cggcagagcc tgcccgccag caatgccctt gtcttcatca ccggctgtga ctcaggcttt gggcgccttc tggcactgca gctggaccag agaggcttcc gagtcctggc cagctgcctg accccctccg gggccgagga cctgcagcgg gtggcctcct cccgcctcca caccaccctg ttggatatca ctgatcccca gagcgtccag caggcagcca agtgggtgga gatgcacgtt aaggaagcag ggctttttgg tctggtgaat aatgctggtg tggctggtat catcggaccc acaccatggc tgacccggga cgatttccag cgggtgctga atgtgaacac aatgggtccc atcggggtca cccttgccct gctgcctctg ctgcagcaag cccggggccg ggtgatcaac atcaccagcg tcctgggtcg cctggcagcc aatggtgggg gctactgtgt ctccaaattt ggcctggagg ccttctctga cagcctgagg cgggatgtag ctcattttgg gatacgagtc tccatcgtgg agcctggctt cttccgaacc cctgtgacca acctggagag tctggagaaa accctgcagg cctgctgggc acggctgcct cctgccacac aggcccacta tgggggggcc ttcctcacca agtacctgaa aatgcaacag cgcatcatga acctgatctg tgacccggac ctaaccaagg tgagccgatg cctggagcat gccctgactg ctcgacaccc ccgaacccgc tacagcccag gttgggatgc caagctgctc tggctgcctg cctcctacct gccagccagc ctggtggatg ctgtgctcac ctgggtcctt cccaagcctg cccaagcagt ctactga. It is sometimes possible for the material contained within the vial of "RDH5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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