Haptoglobin protein Recombinant Protein | HP recombinant protein

Recombinant Rat Haptoglobin protein

Cat. Num. AAA1265546

• Gene Names: Hp; Ba1-647
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Haptoglobin protein; Recombinant Rat Haptoglobin protein; Liver regeneration-related protein LRRG173; Zonulin; HP recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 19-346aa; Partial
• Sequence: VELGNDATDIEDDSCPKPPEIANGYVEHLVRYRCRQFYKLQTEGDGIYTLNSEKQWVNPAAGDKLPKCEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAQNLFLNHSENATAKDIAPTLTLYVGKNQLVEIEKVVLHPERSVVDIGLIKLKQKVLVTEKVMPICLPSKDYVAPGRMGYVSGWGRNVNFRFTERLKYVMLPVADQEKCELHYEKSTVPEKKGAVSPVGVQPILNKHTFCAGLTKYEEDTCYGDAGSAFAVHDTEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAK
• Sequence Length: 347

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for HP recombinant protein

As a result of holysis, hoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hoglobin to allow hepatic recycling of he iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Product Categories/Family for HP recombinant protein

Epigenetics and Nuclear Signaling

References

Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene.Marinkovic S., Baumann H.Mol. Cell. Biol. 10:1573-1583(1990) Liver regeneration after PH.Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B. Nucleotide sequence of rat haptoglobin cDNA. Characterization of the alpha beta-subunit junction region of prohaptoglobin.Goldstein L.A., Heath E.C.J. Biol. Chem. 259:9212-9217(1984) Biosynthesis and processing of rat haptoglobin.Hanley J.M., Haugen T.H., Heath E.C.J. Biol. Chem. 258:7858-7869(1983) Comparative sequence analysis of the N-terminal region of rat, rabbit, and dog haptoglobin beta-chains.Kurosky A., Kim H.H., Touchstone B.Comp. Biochem. Physiol. 55B:453-459(1976) Lubec G., Afjehi-Sadat L.Submitted (DEC-2006) to UniProtKB

NCBI and Uniprot Product Information

• NCBI GI #: 60097941
• NCBI GeneID: 24464
• NCBI Accession #: NP_036714.2
• NCBI GenBank Nucleotide #: NM_012582.2
• UniProt Accession #: P06866; Q5EBB4; Q7TP23
• Molecular Weight: 40.5 kDa
• NCBI Official Full Name: haptoglobin
• NCBI Official Synonym Full Names: haptoglobin
• NCBI Official Symbol: Hp
• NCBI Official Synonym Symbols: Ba1-647
• NCBI Protein Information: haptoglobin
• UniProt Protein Name: Haptoglobin
• UniProt Gene Name: Hp
• UniProt Entry Name: HPT_RAT

NCBI Description

may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]

Uniprot Description

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Enzyme, misc.; Protease; Endoplasmic reticulum; Secreted, signal peptide; Secreted

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: antioxidant activity; hemoglobin binding; protein homodimerization activity; serine-type endopeptidase activity

Biological Process: acute inflammatory response; acute-phase response; defense response to bacterium; immune system process; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; proteolysis; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to X-ray; spermatogenesis