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Western Blot (WB) (All lanes:Haptoglobin antibody at 2ug/ml+rat liver tissue secondary Goat polyclonal to rabbit at 1/10000 dilution predicted band size:39kDa observed band size:39kDa Immunohistochemistry)

Rabbit anti-Rat, Mouse Haptoglobin Polyclonal Antibody | anti-Hp antibody

Rabbit anti-rat Haptoglobin polyclonal Antibody, Biotin conjugated

Gene Names
Hp; Ba1-647
Reactivity
Rat, Mouse
Applications
ELISA
Purity
Caprylic Acid Ammonium Sulfate Precipitation Purified
Synonyms
Haptoglobin; Polyclonal Antibody; Rabbit anti-rat Haptoglobin polyclonal Antibody; Biotin conjugated; Liver regeneration-related protein LRRG173; Zonulin; Hp; Ba1-647; anti-Hp antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Rat, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Sequence Length
347
Applicable Applications for anti-Hp antibody
ELISA (EIA)
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Biotin
Immunogen
Recombinant rat Haptoglobin protein
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(All lanes:Haptoglobin antibody at 2ug/ml+rat liver tissue secondary Goat polyclonal to rabbit at 1/10000 dilution predicted band size:39kDa observed band size:39kDa Immunohistochemistry)

Western Blot (WB) (All lanes:Haptoglobin antibody at 2ug/ml+rat liver tissue secondary Goat polyclonal to rabbit at 1/10000 dilution predicted band size:39kDa observed band size:39kDa Immunohistochemistry)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse liver at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded mouse liver at dilution 1:100)
Related Product Information for anti-Hp antibody
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,475 Da
NCBI Official Full Name
haptoglobin
NCBI Official Synonym Full Names
haptoglobin
NCBI Official Symbol
Hp
NCBI Official Synonym Symbols
Ba1-647
NCBI Protein Information
haptoglobin
UniProt Protein Name
Haptoglobin
Protein Family
UniProt Gene Name
Hp
UniProt Entry Name
HPT_RAT

NCBI Description

may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]

Uniprot Description

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Enzyme, misc.; Endoplasmic reticulum; Protease; Secreted; Secreted, signal peptide

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: antioxidant activity; hemoglobin binding; protein homodimerization activity; serine-type endopeptidase activity

Biological Process: acute inflammatory response; acute-phase response; defense response to bacterium; immune system process; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; proteolysis; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to X-ray; spermatogenesis

Research Articles on Hp

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Product Notes

The Hp hp (Catalog #AAA1490549) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-rat Haptoglobin polyclonal Antibody, Biotin conjugated reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Haptoglobin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the Hp hp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Haptoglobin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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