E3 SUMO-protein ligase PIAS1 (PIAS1) Recombinant Protein | PIAS1 recombinant protein
Recombinant Human E3 SUMO-protein ligase PIAS1 (PIAS1)
RNA helicase II
DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB ().
Research Articles on PIAS1
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Product Notes
The PIAS1 pias1 (Catalog #AAA1263713) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-651, Full length protein. The amino acid sequence is listed below: ADSAELKQMV MSLRVSELQV LLGYAGRNKH GRKHELLTKA LHLLKAGCSP AVQMKIKELY RRRFPQKIMT PADLSIPNVH SSPMPATLSP STIPQLTYDG HPASSPLLPV SLLGPKHELE LPHLTSALHP VHPDIKLQKL PFYDLLDELI KPTSLASDNS QRFRETCFAF ALTPQQVQQI SSSMDISGTK CDFTVQVQLR FCLSETSCPQ EDHFPPNLCV KVNTKPCSLP GYLPPTKNGV EPKRPSRPIN ITSLVRLSTT VPNTIVVSWT AEIGRNYSMA VYLVKQLSST VLLQRLRAKG IRNPDHSRAL IKEKLTADPD SEIATTSLRV SLLCPLGKMR LTIPCRALTC SHLQCFDATL YIQMNEKKPT WVCPVCDKKA PYEHLIIDGL FMEILKYCTD CDEIQFKEDG TWAPMRSKKE VQEVSASYNG VDGCLSSTLE HQVASHHQSS NKNKKVEVID LTIDSSSDEE EEEPSAKRTC PSLSPTSPLN NKGILSLPHQ ASPVSRTPSL PAVDTSYINT SLIQDYRHPF HMTPMPYDLQ GLDFFPFLSG DNQHYNTSLL AAAAAAVSDD QDLLHSSRFF PYTSSQMFLD QLSAGGSTSL PTTNGSSSGS NSSLVSSNSL RESHSHTVTN RSSTDTASIF GIIPDIISLD. It is sometimes possible for the material contained within the vial of "E3 SUMO-protein ligase PIAS1 (PIAS1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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