Proteasome activator BLM10 (BLM10) Recombinant Protein | BLM10 recombinant protein

Recombinant Saccharomyces cerevisiae Proteasome activator BLM10 (BLM10) , partial

• Gene Names: BLM10; YFL006W
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Proteasome activator BLM10 (BLM10); Recombinant Saccharomyces cerevisiae Proteasome activator BLM10 (BLM10); partial; BLM10 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2,143

• Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 37362646
• NCBI GeneID: 850541
• NCBI Accession #: NP_116648.2
• NCBI GenBank Nucleotide #: NM_001179959.1
• UniProt Accession #: P43583; P43584; D6VTM3
• Molecular Weight: 245,996 Da
• NCBI Official Full Name: Blm10p
• NCBI Official Symbol: BLM10
• NCBI Official Synonym Symbols: YFL006W
• NCBI Protein Information: Blm10p
• UniProt Protein Name: Proteasome activator BLM10
• Protein Family: Proteasome activator
• UniProt Gene Name: BLM10
• UniProt Synonym Gene Names: BLM3

Uniprot Description

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks.