Mouse anti-Human ARID4A Monoclonal Antibody | anti-ARID4A antibody

Mouse monoclonal antibody Anti-Human ARID4A

Cat. Num. AAA120383

• Gene Names: ARID4A; RBP1; RBBP1; RBP-1; RBBP-1
• Reactivity: Human
• Applications: Dot Blot
• Synonyms: ARID4A; Monoclonal Antibody; Mouse monoclonal antibody Anti-Human ARID4A; Homo sapiens AT rich interactive domain 4A (RBP1-like) (ARID4A); transcript variant 1; mRNA.; RBP1; RBBP1; RBP-1; anti-ARID4A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 112C4a
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 5792

• Applicable Applications for anti-ARID4A antibody: Dot Blot (DB)
• Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.

Quality Control

(Western blot analysis of immunized recombinant protein, using anti-ARID4A monoclonal antibody. )

Quality Control #2

(Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.)

Related Product Information for anti-ARID4A antibody

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 115334676
• NCBI GeneID: 5926
• NCBI Accession #: NP_002883.3
• NCBI GenBank Nucleotide #: NM_002892
• Molecular Weight: 134,951 Da
• NCBI Official Full Name: Homo sapiens AT rich interactive domain 4A (RBP1-like) (ARID4A), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: AT rich interactive domain 4A (RBP1-like)
• NCBI Official Symbol: ARID4A
• NCBI Official Synonym Symbols: RBP1; RBBP1; RBP-1; RBBP-1
• NCBI Protein Information: AT-rich interactive domain-containing protein 4A; ARID domain-containing protein 4A; retinoblastoma binding protein 1; retinoblastoma-binding protein 1
• UniProt Protein Name: AT-rich interactive domain-containing protein 4A
• Protein Family: AT-rich interactive domain-containing protein
• UniProt Gene Name: ARID4A
• UniProt Entry Name: ARI4A_HUMAN

NCBI Description

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Description

RbBP1: Interacts with the viral protein-binding domain of the retinoblastoma protein. Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.1

Cellular Component: nucleoplasm; transcriptional repressor complex; nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; erythrocyte development; genetic imprinting; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent