Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) Recombinant Protein | PPP1R12B recombinant protein
Recombinant Human Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) , partial
Gene Names
PPP1R12B; MYPT2; PP1bp55
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Protein phosphatase 1 regulatory subunit 12B (PPP1R12B); Recombinant Human Protein phosphatase 1 regulatory subunit 12B (PPP1R12B); partial; PPP1R12B recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Length
1,043
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for PPP1R12B recombinant protein
Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit
myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. There are two MBS subunits; myosin light chain phosphatase target subunit 1 (MYPT1)-MBS is encoded by another gene, and myosin light chain phosphatase target subunit 2 (MYPT2)-MBS is encoded by this gene. sm-M20 shows higher binding affinity to MYPT1-MBS than to MYPT2-MBS, even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, MYPT1-MBS is a more efficient activator. Multiple alternatively spliced transcript variants have been found.
myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. There are two MBS subunits; myosin light chain phosphatase target subunit 1 (MYPT1)-MBS is encoded by another gene, and myosin light chain phosphatase target subunit 2 (MYPT2)-MBS is encoded by this gene. sm-M20 shows higher binding affinity to MYPT1-MBS than to MYPT2-MBS, even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, MYPT1-MBS is a more efficient activator. Multiple alternatively spliced transcript variants have been found.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
116,504 Da
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 12B isoform e
NCBI Official Synonym Full Names
protein phosphatase 1 regulatory subunit 12B
NCBI Official Symbol
PPP1R12B
NCBI Official Synonym Symbols
MYPT2; PP1bp55
NCBI Protein Information
protein phosphatase 1 regulatory subunit 12B
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 12B
Protein Family
UniProt Gene Name
PPP1R12B
UniProt Synonym Gene Names
MYPT2; Myosin phosphatase target subunit 2
NCBI Description
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]
Uniprot Description
Regulates myosin phosphatase activity. Augments Ca2+ sensitivity of the contractile apparatus.
Research Articles on PPP1R12B
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Product Notes
The PPP1R12B ppp1r12b (Catalog #AAA1135535) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Protein phosphatase 1 regulatory subunit 12B (PPP1R12B), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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