GDP-mannose-dependent alpha- (1-6)-phosphatidylinositol monomannoside mannosyltransferase Recombinant Protein | pimB recombinant protein
Recombinant Mycobacterium smegmatis GDP-mannose-dependent alpha- (1-6)-phosphatidylinositol monomannoside mannosyltransferase
NCBI and Uniprot Product Information
Uniprot Description
Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM) (PubMed:10531370, PubMed:19638342). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 6 of a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1) to generate phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2) (PubMed:19638342). PimB also catalyzes the addition of a mannosyl residue from GDP-Man to the position 6 of phosphatidyl-myo-inositol bearing an acylated alpha-1,2-linked mannose residue (Ac1PIM1) to generate monoacylated phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2) (PubMed:19638342). The addition of the second mannosyl residue by PimB preferentially occurs before the acylation of the mannosyl residue transferred by PimA. Also able to transfer a mannosyl residue from GDP-Man to the position 6 of a phosphatidyl-myo-inositol (PI), but this reaction is very slow (PubMed:19638342).
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Product Notes
The pimB pimb (Catalog #AAA1092845) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-382, Full length protein. The amino acid sequence is listed below: MLLVTNDFPP RRGGIQSYLE AFVGELVRTH ELTVYAPKWK GAEEYDEKAA RSGYRVVRHP TTLMLPEPTV ASRMKRLIGE HDIETVWFGA AAPLALLGPL ARRAGARRIV ASTHGHEVGW SMLPVARTAL RRIGNDADVV TFVSRYTRSR FASAFGPSAA LEHLPPGVDT DRFAPDPDAR ARMRERYGLG DRPVVVCLSR LVPRKGQDML IRALPELRRR VPDTALAIVG GGPYLETLQR MASDLGVAEH VVFTRGIPAE ELPAHHAMAD VFAMPCRTRG AGLDVEGLGI VYLEASACGV PVVAGRSGGA PETVLDGKTG TVVDGTDVDA ITTAVGDLLA DPRRAAAMGV AGRHWALDNW QWRTRGARLA ELLSGRREAR QA. It is sometimes possible for the material contained within the vial of "GDP-mannose-dependent alpha- (1-6)-phosphatidylinositol monomannoside mannosyltransferase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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