Bcl-2-like protein 1 (BCL2L1) Recombinant Protein | BCL2L1 recombinant protein

Recombinant Pig Bcl-2-like protein 1 (BCL2L1)

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Bcl-2-like protein 1 (BCL2L1); Recombinant Pig Bcl-2-like protein 1 (BCL2L1); Recombinant Bcl-2-like protein 1 (BCL2L1); Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; BCL2L1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-233
• Sequence: MSQSNRELVVDFLSYKLSQKGYSWSQFTDVEENRTEAPEGTESEAETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVLNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIATWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTLAGVVLLGSLFSRK
• Sequence Length: 233

• Species: Sus scrofa (Pig)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 47523644
• NCBI GeneID: 397536
• NCBI Accession #: NP_999450.1
• NCBI GenBank Nucleotide #: NM_214285.1
• UniProt Accession #: O77737
• Molecular Weight: 26,061 Da
• NCBI Official Full Name: bcl-2-like protein 1
• NCBI Official Symbol: BCL2L1
• NCBI Protein Information: bcl-2-like protein 1; bcl2-L-1; anti-apoptotic Bcl-xL; apoptosis regulator Bcl-X
• UniProt Protein Name: Bcl-2-like protein 1
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: BCL2L1
• UniProt Synonym Gene Names: BCLX; BLC2L; Bcl2-L-1
• UniProt Entry Name: B2CL1_PIG

Uniprot Description

Function: Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1.Inhibits activation of caspases

By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis

By similarity.

Subunit structure: Bcl-X(L) forms heterodimers with BAX, BAK and BCL2

By similarity. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity

By similarity. Also interacts with BBC3

By similarity. Isoform Bcl-X(L) binds to Siva isoform 1. Interacts with BECN1, BCL2L11 and PGAM5

By similarity. Isoform Bcl-X(L) interacts with IKZF3

By similarity. Interacts with HEBP2

By similarity.

Subcellular location: Mitochondrion membrane; Single-pass membrane protein

By similarity. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side

By similarity. Cytoplasm › cytoskeleton › centrosome

By similarity. Note: Mitochondrial membranes and perinuclear envelope

By similarity.

Domain: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.

Post-translational modification: Proteolytically cleaved by caspases during apoptosis

By similarity. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity

By similarity.Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis

By similarity.

Sequence similarities: Belongs to the Bcl-2 family.