Ubiquitin carboxyl-terminal hydrolase 4 (DOA4) Recombinant Protein | DOA4 recombinant protein

Recombinant Saccharomyces cerevisiae Ubiquitin carboxyl-terminal hydrolase 4 (DOA4), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase 4 (DOA4); Recombinant Saccharomyces cerevisiae Ubiquitin carboxyl-terminal hydrolase 4 (DOA4); partial; DOA4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 926

• Species: Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 239977664
• UniProt Accession #: B3LGK1
• Molecular Weight: 105,188 Da
• NCBI Official Full Name: Ubiquitin carboxyl-terminal hydrolase 4
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 4
• UniProt Gene Name: DOA4
• UniProt Synonym Gene Names: DOS1; MUT4; NPI2; SSV7; UBP4

Uniprot Description

Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Removes also ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Involved in the ammonium-induced down-regulation of the GAP1 permease and the UME3 destruction in response to oxidative stress. Has a role in the RAD9 checkpoint response to TOP1 poisons. Required for promoting coordination of DNA replication and avoids DNA overreplication ().