Structure
Diarylpropionitrile Biochemical
Diarylpropionitrile
Purity
>98% (HPLC)
Synonyms
Diarylpropionitrile; DPN; Diarylpropionitrile biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Estrogen Receptor/ERR
Receptor
Estrogen Receptor/ERR
Chemical Name
Benzenepropanenitrile, 4-hydroxy-alpha-(4-hydroxyphenyl)
SMILES
C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
Molecular Formula
C15H13NO2
CAS Number
1428-67-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Diarylpropionitrile biochemical
Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor beta (ERbeta) selective ligand, demonstrates the neuroprotective effects against 10 0M Abeta1-42-induced oxidative stress and inflammation in primary rat cortical cell culture; (1-100nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1beta and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.
Product Categories/Family for Diarylpropionitrile biochemical
References
1. Suwanna N, et al. Neurosci Lett. 2014 Aug 22; 578:44-9.
2. Khalaj AJ, et al. Proc Natl Acad Sci U S A. 2013 Nov 19; 110 (47):19125-30.
3. Mancuso M, et al. Cancer Lett. 2011 Sep 28; 308 (2):197-202.
4. Motylewska E, et al. Cancer Lett. 2009 Apr 8; 276 (1):68-73.
2. Khalaj AJ, et al. Proc Natl Acad Sci U S A. 2013 Nov 19; 110 (47):19125-30.
3. Mancuso M, et al. Cancer Lett. 2011 Sep 28; 308 (2):197-202.
4. Motylewska E, et al. Cancer Lett. 2009 Apr 8; 276 (1):68-73.
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Product Notes
The Diarylpropionitrile (Catalog #AAA3601807) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Diarylpropionitrile, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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