Zinc finger protein ZIC 2 (ZIC2) Recombinant Protein | ZIC2 recombinant protein
Recombinant Human Zinc finger protein ZIC 2 (ZIC2), partial
Gene Names
ZIC2; HPE5
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Zinc finger protein ZIC 2 (ZIC2); Recombinant Human Zinc finger protein ZIC 2 (ZIC2); partial; Zinc finger protein of the cerebellum 2; ZIC2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
100-415aa, Partial
Sequence
PHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVH
Species
Homo sapiens (Human)
Relevance
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Product Categories/Family for ZIC2 recombinant protein
References
"ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A."Ishiguro A., Ideta M., Mikoshiba K., Chen D.J., Aruga J.J. Biol. Chem. 282:9983-9995(2007)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,006 Da
NCBI Official Full Name
zinc finger protein ZIC 2
NCBI Official Synonym Full Names
Zic family member 2
NCBI Official Symbol
ZIC2
NCBI Official Synonym Symbols
HPE5
NCBI Protein Information
zinc finger protein ZIC 2; Zinc finger protein of the cerebellum 2; Zic family member 2 (odd-paired homolog, Drosophila)
UniProt Protein Name
Zinc finger protein ZIC 2
Protein Family
UniProt Gene Name
ZIC2
UniProt Entry Name
ZIC2_HUMAN
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Product Notes
The ZIC2 zic2 (Catalog #AAA9018535) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 100-415aa, Partial. The amino acid sequence is listed below: PHAAHVGSYS GPPFNSTRDF LFRSRGFGDS APGGGQHGLF GPGAGGLHHA HSDAQGHLLF PGLPEQHGPH GSQNVLNGQM RLGLPGEVFG RSEQYRQVAS PRTDPYSAAQ LHNQYGPMNM NMGMNMAAAA AHHHHHHHHH PGAFFRYMRQ QCIKQELICK WIDPEQLSNP KKSCNKTFST MHELVTHVSV EHVGGPEQSN HVCFWEECPR EGKPFKAKYK LVNHIRVHTG EKPFPCPFPG CGKVFARSEN LKIHKRTHTG EKPFQCEFEG CDRRFANSSD RKKHMHVHTS DKPYLCKMCD KSYTHPSSLR KHMKVH. It is sometimes possible for the material contained within the vial of "Zinc finger protein ZIC 2 (ZIC2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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