Human zinc fingers and homeoboxes 1 ELISA Kit | ZHX1 elisa kit
Human Zinc fingers and homeoboxes protein 1, ZHX1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Uniprot Description
ZHX1: Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co- repressor proteins. Belongs to the ZHX family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; metal ion binding; transcription corepressor activity; transcription factor activity
Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transcription, DNA-dependent
Research Articles on ZHX1
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Product Notes
The Human ZHX1 zhx1 (Catalog #AAA9321622) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321622 ELISA Kit recognizes Human ZHX1. It is sometimes possible for the material contained within the vial of "zinc fingers and homeoboxes 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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