Terminal uridylyltransferase 7 (ZCCHC6) Recombinant Protein | ZCCHC6 recombinant protein

Recombinant Human Terminal uridylyltransferase 7 (ZCCHC6) , partial

• Gene Names: ZCCHC6; TUT7; PAPD6
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Terminal uridylyltransferase 7 (ZCCHC6); Recombinant Human Terminal uridylyltransferase 7 (ZCCHC6); partial; ZCCHC6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,457

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 297307111
• NCBI GeneID: 79670
• NCBI Accession #: NP_001171988.1
• NCBI GenBank Nucleotide #: NM_001185059.1
• UniProt Accession #: Q5VYS8; Q5H9T0; Q5VYS5; Q5VYS7; Q658Z9; Q659A2; Q6MZJ3; Q8N5F0; Q96N57; Q96NE8; Q9C0F2; Q9H8M6
• Molecular Weight: 166,970 Da
• NCBI Official Full Name: terminal uridylyltransferase 7 isoform 1
• NCBI Official Synonym Full Names: zinc finger CCHC-type containing 6
• NCBI Official Symbol: ZCCHC6
• NCBI Official Synonym Symbols: TUT7; PAPD6
• NCBI Protein Information: terminal uridylyltransferase 7
• UniProt Protein Name: Terminal uridylyltransferase 7
• Protein Family: Terminal uridylyltransferase
• UniProt Gene Name: ZCCHC6
• UniProt Synonym Gene Names: HS2; KIAA1711; TUT7; TUTase 7

Uniprot Description

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.