Human YME1-like 1 (S. cerevisiae) ELISA Kit | YME1L1 elisa kit
Human ATP-dependent zinc metalloprotease YME1L1, YME1L1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
YME1L1: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Protease; Mitochondrial
Chromosomal Location of Human Ortholog: 10p14
Cellular Component: membrane; mitochondrial inner membrane; integral to membrane
Molecular Function: metal ion binding; metalloendopeptidase activity; ATP binding
Biological Process: cell proliferation; mitochondrion organization and biogenesis; misfolded or incompletely synthesized protein catabolic process
Research Articles on YME1L1
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Product Notes
The Human YME1L1 yme1l1 (Catalog #AAA9330370) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330370 ELISA Kit recognizes Human YME1L1. It is sometimes possible for the material contained within the vial of "YME1-like 1 (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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