XIAP-associated factor 1 (Xaf1) Recombinant Protein | Xaf1 recombinant protein
Recombinant Mouse XIAP-associated factor 1 (Xaf1)
NCBI and Uniprot Product Information
Uniprot Description
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells ().
Research Articles on Xaf1
Similar Products
Product Notes
The Xaf1 xaf1 (Catalog #AAA1370575) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-273, full length protein. The amino acid sequence is listed below: MEADFQVCRN CKRNVASLHF MLHEAHCLRF IVLCPECEEP IPESKMKEHM EVVHQQTKES QQHPAKCKFC ELAVQLSNLD VHESHCGSRT EHCPHCNQPI TLQVLSQHKA MCLSAKGRPE EGKRIVSSPG RKTRCDLCKQ MIPENTYASH MKQCSAPNTV TRIRDESIIV IPSTLAFMDS GNRRSTVSKD VRPKTKNRNS STKRETKKQN GTVALPLKSG LQQRADLPTG DETAYDTLQN CCQCRILLPL PILNEHQEKC QRLAHQKKLQ WGW. It is sometimes possible for the material contained within the vial of "XIAP-associated factor 1 (Xaf1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
