NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) Recombinant Protein | WWP1 recombinant protein

Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) , partial

• Gene Names: WWP1; AIP5; Tiul1; hSDRP1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1); Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1); partial; WWP1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 922

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for WWP1 recombinant protein

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.

NCBI and Uniprot Product Information

• NCBI GI #: 13654239
• NCBI GeneID: 11059
• NCBI Accession #: NP_008944.1
• NCBI GenBank Nucleotide #: NM_007013.3
• UniProt Accession #: Q9H0M0; O00307; Q5YLC1; Q96BP4
• Molecular Weight: – Da
• NCBI Official Full Name: NEDD4-like E3 ubiquitin-protein ligase WWP1
• NCBI Official Synonym Full Names: WW domain containing E3 ubiquitin protein ligase 1
• NCBI Official Symbol: WWP1
• NCBI Official Synonym Symbols: AIP5; Tiul1; hSDRP1
• NCBI Protein Information: NEDD4-like E3 ubiquitin-protein ligase WWP1
• UniProt Protein Name: NEDD4-like E3 ubiquitin-protein ligase WWP1
• Protein Family: NEDD4-like E3 ubiquitin-protein ligase
• UniProt Gene Name: WWP1
• UniProt Synonym Gene Names: AIP5; Tiul1

NCBI Description

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.