Werner syndrome ATP-dependent helicase homolog (wrn) Recombinant Protein | wrn recombinant protein

Recombinant Xenopus laevis Werner syndrome ATP-dependent helicase homolog (wrn), partial

• Gene Names: wrn.L; wrn; xwrn; ffa-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Werner syndrome ATP-dependent helicase homolog (wrn); Recombinant Xenopus laevis Werner syndrome ATP-dependent helicase homolog (wrn); partial; wrn recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,436

• Species: Xenopus laevis (African clawed frog)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 148227808
• NCBI GeneID: 398079
• NCBI Accession #: NP_001081838.1
• NCBI GenBank Nucleotide #: NM_001088369.1
• UniProt Accession #: O93530
• Molecular Weight: 161,851 Da
• NCBI Official Full Name: Werner syndrome ATP-dependent helicase homolog
• NCBI Official Synonym Full Names: Werner syndrome, RecQ helicase-like L homeolog
• NCBI Official Symbol: wrn.L
• NCBI Official Synonym Symbols: wrn; xwrn; ffa-1
• NCBI Protein Information: Werner syndrome ATP-dependent helicase homolog
• UniProt Protein Name: Werner syndrome ATP-dependent helicase homolog
• Protein Family: Werner syndrome ATP-dependent helicase
• UniProt Gene Name: wrn
• UniProt Synonym Gene Names: ffa1; FFA-1

Uniprot Description

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A ().