WASP homolog-associated protein with actin, membranes and microtubules (Whamm) Recombinant Protein | Whamm recombinant protein

Recombinant Mouse WASP homolog-associated protein with actin, membranes and microtubules (Whamm)

Cat. Num. AAA1343744

• Gene Names: Whamm; Whdc1; BB081391; mKIAA1971
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WASP homolog-associated protein with actin; membranes and microtubules (Whamm); Recombinant Mouse WASP homolog-associated protein with actin; Whamm recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-793, Full length protein
• Sequence: MDSEQPDSLDGWVPLREDLFPEPERHQLRFLVAWNAAKGQFAVTCHDRTAQRRRRERREAGDGGCSWAGVLSPAGFRGAHRQLAALWPALEPCFPPLPPELDAASGAGWGLGRGLWALLWPLLWPAPADPGDSALQELCRQLEHYLGLAAEGCGGATVRDVLFPAPGDSADCEGLSEFRERTLRARLGQTATRLHQVLQDHGKANTMVALMKVYQEEDELYQELVTMATTFFQYLLQPFRDMREVATSCKLGILKSLDEDELGPRRVAALQKEASEWTRQAEEAVGSIQDITVNYFKETVTALTGMQKQMEQDQKRFGQAAWATAMPRLENLKLMLARETLQLMRAKELCLKHRQAEIQRKVEDLPRQGKQLDVVDELEIQCYEIQLELYDVKLEMLRNEETILVTRLDSVKRLITEKQAEVIYYDPCESPEELQSLAPDLELHLGDNRELRALSQQCQRLEAQRGRICSRRALLRNRKDHCRENHQLRLQQAKQSLRHLHQHHSIQMKRDKVKEEEQKKKEWIDHERQKTLERLRAYKEKCPAHRSALKTTCSESMVSNLPGGRSQKRLSTAHHHKTAHPASSKTGSAVPLPEASVRPPEHQDPCGSVPVQAFVPVSDQTLSGSSEDLSLPPQPPAPPLPPPPPPPPPPPLPPALSSFQGTTHQNLGLRTLATEDRPLPLACDPSAGRPCDYQGPGSMDEVLASLRQGKASLRKVETPTLPHPGTSVNEQVLAAIRQGVQLKKVHTGQGVDPGKKSTSDLERSIREALERIKKVSADSEEDNDEPSPTEWDR
• Sequence Length: 793

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 161484680
• NCBI GeneID: 434204
• NCBI Accession #: NP_001004185.3
• NCBI GenBank Nucleotide #: NM_001004185.3
• UniProt Accession #: Q571B6; Q80VK9; Q80YT0; Q8BJP8
• Molecular Weight: 56,418 Da
• NCBI Official Full Name: WASP homolog-associated protein with actin, membranes and microtubules
• NCBI Official Synonym Full Names: WAS protein homolog associated with actin, golgi membranes and microtubules
• NCBI Official Symbol: Whamm
• NCBI Official Synonym Symbols: Whdc1; BB081391; mKIAA1971
• NCBI Protein Information: WASP homolog-associated protein with actin, membranes and microtubules
• UniProt Protein Name: WASP homolog-associated protein with actin, membranes and microtubules
• Protein Family: WASP homolog-associated protein
• UniProt Gene Name: Whamm
• UniProt Synonym Gene Names: Kiaa1971; Whdc1; WH2 domain-containing protein 1

Uniprot Description

Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration (). Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex.