Interleukin-3 (IL-3) Western Blot Control | IL-3 western blot control

Interleukin-3 (IL-3) (Western Blot Control)

Cat. Num. AAA343072

• Gene Names: IL3; IL-3; MCGF; MULTI-CSF
• Purity: >= 95% (SDS PAGE)
• Synonyms: Interleukin-3 (IL-3); Interleukin-3 (IL-3) (Western Blot Control); IL-3; Multi-potential Colony Stimulating Factor (MCSF); Hematopoietic Growth Factor; P-Cell Stimulating Factor; Mast Cell Growth Factor (MCGF); Multi-lineage Colony Stimulating Factor.; IL-3 western blot control

• Purity/Purification: >= 95% (SDS PAGE)
• Form/Format: Liquid
• Sequence Length: 152

• Buffer: Buffered 50% glycerol

Related Product Information for IL-3 western blot control

Interleukin-3 is a pleiotropic cytokine produced primarily by activated T cells. IL-3 is thought to function via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines. IL-3 has also been shown to affect the functional activity of a variety of other cell types including mast cells, eosinophils, megakaryocytes and basophils. Recombinant Interleukin-3 comprises a 133 amino acid fragment (20-152) corresponding to the mature Interleukin-3 protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Product Categories/Family for IL-3 western blot control

Recombinant Proteins; Interleukin-3

References

Lindemann A. & Mertelsmann R. (1993) Cancer Invest. 11(5): 609- 623.

NCBI and Uniprot Product Information

• NCBI GI #: 28416915
• NCBI GeneID: 3562
• NCBI Accession #: NP_000579.2
• NCBI GenBank Nucleotide #: NM_000588.3
• UniProt Accession #: P08700; Q6GS87
• Molecular Weight: 17,233 Da
• NCBI Official Full Name: interleukin-3
• NCBI Official Synonym Full Names: interleukin 3
• NCBI Official Symbol: IL3
• NCBI Official Synonym Symbols: IL-3; MCGF; MULTI-CSF
• NCBI Protein Information: interleukin-3
• UniProt Protein Name: Interleukin-3
• Protein Family: Interleukin
• UniProt Gene Name: IL3
• UniProt Synonym Gene Names: IL-3; MCGF
• UniProt Entry Name: IL3_HUMAN

NCBI Description

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Uniprot Description

IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Cytokine; Secreted; Cell cycle regulation; Secreted, signal peptide; Oncoprotein; Apoptosis

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-3 receptor binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell-cell signaling; cytokine and chemokine mediated signaling pathway; embryonic hemopoiesis; MAPKKK cascade; nervous system development; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein