Cytokeratin-18 (CK-18) Western Blot Control | CK-18 western blot control
Cytokeratin-18 (CK-18) (Western Blot Control)
NCBI and Uniprot Product Information
NCBI Description
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis.
Protein type: Cytoskeletal; Nucleolus
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: cytoplasm; intermediate filament; keratin filament; microtubule organizing center
Molecular Function: protein binding
Biological Process: anatomical structure morphogenesis; Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization and biogenesis; negative regulation of apoptosis
Disease: Cirrhosis, Familial
Research Articles on CK-18
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Product Notes
The CK-18 krt18 (Catalog #AAA343013) is a Western Blot Control and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cytokeratin-18 (CK-18), Western Blot Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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