WD repeat-containing protein 5 Recombinant Protein | WDR5 recombinant protein

Recombinant Human WD repeat-containing protein 5

Cat. Num. AAA9420803

• Gene Names: WDR5; SWD3; BIG-3; CFAP89
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: WD repeat-containing protein 5; Recombinant Human WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WDR5 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 2-334aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for WDR5 recombinant protein

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 16554627
• NCBI GeneID: 11091
• NCBI Accession #: NP_060058.1
• NCBI GenBank Nucleotide #: NM_017588.2
• UniProt Accession #: P61964; Q91VA5; Q9NWX7; Q9UGP9
• Molecular Weight: 52.4kD
• NCBI Official Full Name: WD repeat-containing protein 5
• NCBI Official Synonym Full Names: WD repeat domain 5
• NCBI Official Symbol: WDR5
• NCBI Official Synonym Symbols: SWD3; BIG-3; CFAP89
• NCBI Protein Information: WD repeat-containing protein 5
• UniProt Protein Name: WD repeat-containing protein 5
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR5
• UniProt Synonym Gene Names: BIG3

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity (H4-K16 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding

Biological Process: histone H3-K4 methylation; post-translational protein modification