Rat vacuolar protein sorting 4 homolog A (S. cerevisiae) ELISA Kit | VPS4A elisa kit
Rat Vacuolar protein sorting-associated protein 4A, VPS4A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds Rho family GTPase Rnd2; may play a role in endosomal trafficking [RGD, Feb 2006]
Uniprot Description
VPS4A: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis. Belongs to the AAA ATPase family.
Protein type: Vesicle; EC 3.6.4.6
Cellular Component: spindle pole; centrosome; perinuclear region of cytoplasm; late endosome membrane; early endosome; cytoplasm; midbody; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; Rho GTPase binding; microtubule-severing ATPase activity; ATP binding
Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body pathway; cell separation during cytokinesis; metabolic process; endosome transport; mitotic metaphase plate congression; cytoplasmic microtubule organization and biogenesis; negative regulation of cytokinesis; vesicle-mediated transport; protein transport; cell division; abscission; nuclear organization and biogenesis; vacuole organization and biogenesis
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Product Notes
The Rat VPS4A vps4a (Catalog #AAA9322989) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322989 ELISA Kit recognizes Rat VPS4A. It is sometimes possible for the material contained within the vial of "vacuolar protein sorting 4 homolog A (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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