VEGFC recombinant protein

VEGFC protein (Rat) (152s)

Cat. Num. AAA538015

• Applications: User optimized
• Purity: > 90% pure
• Synonyms: VEGFC; VEGFC protein (Rat) (152s); Rat VEGF-C 152s protein; Vascular Endothelial Growth Factor C 152s protein; VEGFC recombinant protein

• Host: Rat
• Purity/Purification: > 90% pure
• Form/Format: Lyophilized (soluble in water and most aqueous buffers). Reconstitute in PBS or medium to a concentration not lower than 50ug/ml.
• Sequence Length: 415

• Applicable Applications for VEGFC recombinant protein: User optimized
• Protein Type: Recombinant
• Biological Significance: VEGF-C152S is a point mutant generated by the replacement of the second conserved Cys residue of the recombinant processed VEGF-C by a Ser residue. VEGF-C152S is analog to the human VEGF-C156S mutant and only active toward VEGFR-3/FLT-4 but, unlike wild type VEGF-C, is unable to bind to and to activate signalling through VEGFR-2/kDaR. VEGF C152S was inactive in the vascular permeability assay and did not increase migration of the capillary endothelial cells, indicating that these VEGF-like effects of VEGF-C require VEGFR-2 binding. VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein.
• Endotoxin Levels: <0.1 ng per ug of VEGF-C152S
• Expression System: Sf-9 insect cells
• Preparation and Storage: Ships ambient or refrigerated. Upon receipt store at -20 degreeree C. Avoid repeated freeze/thaw cycles.

Related Product Information for VEGFC recombinant protein

Purified recombinant Rat VEGFC protein (152s)

Product Categories/Family for VEGFC recombinant protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 16758992
• NCBI GeneID: 114111
• NCBI Accession #: NP_446105.1
• NCBI GenBank Nucleotide #: NM_053653.1
• UniProt Accession #: O35757; Q91ZE3
• Molecular Weight: 18-24 kDa
• NCBI Official Full Name: vascular endothelial growth factor C
• NCBI Official Synonym Full Names: vascular endothelial growth factor C
• NCBI Official Symbol: Vegfc
• NCBI Protein Information: vascular endothelial growth factor C
• UniProt Protein Name: Vascular endothelial growth factor C
• Protein Family: Vascular endothelial growth factor
• UniProt Gene Name: Vegfc
• UniProt Synonym Gene Names: VEGF-C; Flt4-L; VRP
• UniProt Entry Name: VEGFC_RAT

NCBI Description

platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth [RGD, Feb 2006]

Uniprot Description

VEGFC: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family.

Protein type: Secreted, signal peptide; Cell cycle regulation; Cytokine; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; membrane

Molecular Function: growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity

Biological Process: response to drug; positive regulation of neuroblast proliferation; positive regulation of blood vessel endothelial cell migration; regulation of angiogenesis; positive regulation of protein amino acid autophosphorylation; induction of positive chemotaxis; negative regulation of cell proliferation; positive regulation of angiogenesis; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; morphogenesis of embryonic epithelium; positive regulation of protein secretion; positive chemotaxis; positive regulation of cell division; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell proliferation; angiogenesis; negative regulation of blood pressure; positive regulation of cell-matrix adhesion; vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation