VCAM1 recombinant protein

VCAM1, 25-698aa, Human, His tag, E Coli

Cat. Num. AAA204633

• Gene Names: VCAM1; CD106; INCAM-100
• Applications: SDS-Page
• Purity: > 80% by SDS-PAGE
• Synonyms: VCAM1; 25-698aa; Human; His tag; E Coli; Vascular cell adhesion molecule 1; CD106; DKFZp 779G2333; INCAM-100; MGC99561; VCAM1 recombinant protein

• Host: E Coli
• Purity/Purification: > 80% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
• Concentration: 0.25 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MFKIETTPES RYLAQIGDSV SLTCSTTGCE SPFFSWRTQI DSPLNGKVTN EGTTSTLTMN PVSFGNEHSY LCTATCESRK LEKGIQVEIY SFPKDPEIHL SGPLEAGKPI TVKCSVADVY PFDRLEIDLL KGDHLMKSQE FLEDADRKSL ETKSLEVTFT PVIEDIGKVL VCRAKLHIDE MDSVPTVRQA VKELQVYISP KNTVISVNPS TKLQEGGSVT MTCSSEGLPA PEIFWSKKLD NGNLQHLSGN ATLTLIAMRM EDSGIYVCEG VNLIGKNRKE VELIVQEKPF TVEISPGPRI AAQIGDSVML TCSVMGCESP SFSWRTQIDS PLSGKVRSEG TNSTLTLSPV SFENEHSYLC TVTCGHKKLE KGIQVELYSF PRDPEIEMSG GLVNGSSVTV SCKVPSVYPL DRLEIELLKG ETILENIEFL EDTDMKSLEN KSLEMTFIPT IEDTGKALVC QAKLHIDDME FEPKQRQSTQ TLYVNVAPRD TTVLVSPSSI LEEGSSVNMT CLSQGFPAPK ILWSRQLPNG ELQPLSENAT LTLISTKMED SGVYLCEGIN QAGRSRKEVE LIIQVTPKDI KLTAFPSESV KEGDTVIISC TCGNVPETWI ILKKKAETGD TVLKSIDGAY TIRKAQLKDA GVYECESKNK VGSQLRSLTL DVQGRENNKD YFSPE
• Sequence Length: 739

• Applicable Applications for VCAM1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for VCAM1 recombinant protein

VCAM1 is a member of the Ig superfamily and is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Recombinant human VCAM1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for VCAM1 recombinant protein

Cancer

References

Wu TC (2007) Cancer Res. 67 (13): 6003-6.

NCBI and Uniprot Product Information

• NCBI GI #: 4507875
• NCBI GeneID: 7412
• NCBI Accession #: NP_001069
• NCBI GenBank Nucleotide #: NM_001078.3
• UniProt Accession #: P19320; Q6NUP8; A8K6R7; B4DKS4; E9PDD1
• Molecular Weight: 76 kDa (695aa)
• NCBI Official Full Name: vascular cell adhesion protein 1 isoform a
• NCBI Official Synonym Full Names: vascular cell adhesion molecule 1
• NCBI Official Symbol: VCAM1
• NCBI Official Synonym Symbols: CD106; INCAM-100
• NCBI Protein Information: vascular cell adhesion protein 1
• UniProt Protein Name: Vascular cell adhesion protein 1
• Protein Family: Vascular cell adhesion protein
• UniProt Gene Name: VCAM1
• UniProt Synonym Gene Names: V-CAM 1; VCAM-1

NCBI Description

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.