Guanine nucleotide exchange factor VAV3 (Vav3) Recombinant Protein | Vav3 recombinant protein

Recombinant Mouse Guanine nucleotide exchange factor VAV3 (Vav3) , partial

• Gene Names: Vav3; Idd18.1; AA986410; A530094I06Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Guanine nucleotide exchange factor VAV3 (Vav3); Recombinant Mouse Guanine nucleotide exchange factor VAV3 (Vav3); partial; Vav3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 574

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Vav3 recombinant protein

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 69724858
• NCBI GeneID: 57257
• NCBI Accession #: NP_065251.2
• NCBI GenBank Nucleotide #: NM_020505.2
• UniProt Accession #: Q9R0C8; Q7TS85; Q8BRV2; Q8CCF5; Q8R076; Q9JLS6; A2CFD7
• Molecular Weight: 66,849 Da
• NCBI Official Full Name: guanine nucleotide exchange factor VAV3 isoform 1
• NCBI Official Synonym Full Names: vav 3 oncogene
• NCBI Official Symbol: Vav3
• NCBI Official Synonym Symbols: Idd18.1; AA986410; A530094I06Rik
• NCBI Protein Information: guanine nucleotide exchange factor VAV3
• UniProt Protein Name: Guanine nucleotide exchange factor VAV3
• Protein Family: Guanine nucleotide exchange factor
• UniProt Gene Name: Vav3
• UniProt Synonym Gene Names: VAV-3

Uniprot Description

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.