Synaptobrevin-3 Recombinant Protein | VAMP3 recombinant protein

Recombinant Human Synaptobrevin-3

Cat. Num. AAA143456

• Gene Names: VAMP3; CEB
• Purity: Greater than 95.0% as determined by: ; ; (a) Analysis by RP-HPLC. ; (b) Analysis by SDS-PAGE.
• Synonyms: Synaptobrevin-3; Recombinant Human Synaptobrevin-3; VAMP3 Human; Synaptobrevin-3 Human Recombinant; VAMP3; VAMP-3; Cellubrevin; Vesicle-Associated Membrane Protein 3; CEB; SYB3; VAMP3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by: ; ; (a) Analysis by RP-HPLC. ; (b) Analysis by SDS-PAGE.
• Form/Format: The VAMP3 protein solution (1mg/mL) contains 20mM Tris pH-7.5 and 10% glycerol.
• Sequence: MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA DALQAGASQF ETSAAKLKRK YWWKNCK
• Sequence Length: 100

• Physical Apperance: Sterile filtered colorless solution.
• Preparation and Storage: Store at 4°C if entire viall will be used within 2-4 weeks.; Store frozen at -20°C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze/thaw cycles.

Related Product Information for VAMP3 recombinant protein

Description: VAMP3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa.

Introduction: VAMP3 is present in recycling endosomes and endosome-derived vesicles. VAMP3 has been implicated in recycling of transferrin receptors to the plasma membrane, secretion of alpha-granules in platelets, recycling of T-cell receptors to the immunological synapses, and membrane trafficking during cell migration. VAMP-3 is present in human platelets and necessary for granule secretion. Synaptobrevins are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 high homology to other VAMPs in its broad tissue distribution and subcellular localization is shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.

Product Categories/Family for VAMP3 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Synaptobrevin

NCBI and Uniprot Product Information

• NCBI GI #: 4759300
• NCBI GeneID: 9341
• NCBI Accession #: NP_004772.1
• NCBI GenBank Nucleotide #: NM_004781.3
• UniProt Accession #: Q15836; Q9BRV4
• Molecular Weight: 11,309 Da
• NCBI Official Full Name: vesicle-associated membrane protein 3
• NCBI Official Synonym Full Names: vesicle-associated membrane protein 3
• NCBI Official Symbol: VAMP3
• NCBI Official Synonym Symbols: CEB
• NCBI Protein Information: vesicle-associated membrane protein 3; VAMP-3; cellubrevin; synaptobrevin-3
• UniProt Protein Name: Vesicle-associated membrane protein 3
• Protein Family: Vesicle-associated membrane protein
• UniProt Gene Name: VAMP3
• UniProt Synonym Gene Names: SYB3; VAMP-3; CEB
• UniProt Entry Name: VAMP3_HUMAN

NCBI Description

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Uniprot Description

VAMP3: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Belongs to the synaptobrevin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: neuron projection; cell surface; intracellular membrane-bound organelle; clathrin-coated vesicle; integral to membrane; clathrin coated vesicle membrane; cytosol; secretory granule; SNARE complex; synaptic vesicle; recycling endosome; apical plasma membrane; plasma membrane; intracellular; cell junction

Molecular Function: SNAP receptor activity; SNARE binding; protein binding; syntaxin-1 binding

Biological Process: vesicle-mediated transport; vesicle fusion; exocytosis; neurotransmitter secretion; Golgi to plasma membrane protein transport; protein complex assembly; positive regulation of immunoglobulin secretion; retrograde transport, endosome to Golgi; positive regulation of receptor recycling; vesicle docking during exocytosis; calcium ion-dependent exocytosis