Ubiquitously-Expressed, Prefoldin-Like Chaperone Recombinant Protein | UXT recombinant protein

Recombinant Human Ubiquitously-Expressed, Prefoldin-Like Chaperone

Cat. Num. AAA146079

• Gene Names: UXT; STAP1; ART-27
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Ubiquitously-Expressed; Prefoldin-Like Chaperone; Recombinant Human Ubiquitously-Expressed; UXT Human; Prefoldin-Like Chaperone Human Recombinant; Protein UXT; Androgen receptor trapped clone 27 protein; ART-27; Ubiquitously expressed transcript protein; UXT; HSPC024; STAP1; UXT recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: UXT protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL QLRNVIERLQ EAKHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL SNSLTKDSMN IKAHIHMLLE GLRELQGLQN FPEKPHH.
• Sequence Length: 157

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for UXT recombinant protein

Description: UXT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (1-157 a.a.) and having a molecular mass of 20.4kDa.UXT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Ubiquitously-expressed transcript (UXT) is a member of the UXT family. UXT serves as a cofactor which modulates androgen receptor-dependent transcription, and also has a crucial role in tumor necrosis factor-induced apoptosis. UXT gene expression has a role in tumorigenesis. UXT is ubiquitous expressed: it is expressed in prostate epithelial cells, overexpressed in a number of tumor tissues. The highest levels are found in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.

Product Categories/Family for UXT recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4759298
• NCBI GeneID: 8409
• NCBI Accession #: NP_004173.1
• NCBI GenBank Nucleotide #: NM_004182.3
• UniProt Accession #: Q9UBK9; Q5JZG3; Q9Y6E5; B2R561
• Molecular Weight: 18,246 Da
• NCBI Official Full Name: protein UXT isoform 2
• NCBI Official Synonym Full Names: ubiquitously-expressed, prefoldin-like chaperone
• NCBI Official Symbol: UXT
• NCBI Official Synonym Symbols: STAP1; ART-27
• NCBI Protein Information: protein UXT; SKP2-associated alpha PFD 1; androgen receptor trapped clone 27 protein; ubiquitously expressed transcript protein
• UniProt Protein Name: Protein UXT
• Protein Family: Protein
• UniProt Gene Name: UXT
• UniProt Synonym Gene Names: ART-27
• UniProt Entry Name: UXT_HUMAN

NCBI Description

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

UXT: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. Belongs to the UXT family.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xp11.23-p11.22

Cellular Component: centrosome; cytoskeleton; cytoplasm; nucleus; gamma-tubulin complex

Molecular Function: actin filament binding; protein binding; microtubule binding; beta-tubulin binding; chromatin binding

Biological Process: transcription, DNA-dependent; centrosome organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule