Ubiquitin carboxyl-terminal hydrolase 2 (Usp2) Recombinant Protein | Usp2 recombinant protein

Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 2 (Usp2)

Cat. Num. AAA1121201

• Gene Names: Usp2; Ubp41; B930035K21Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin carboxyl-terminal hydrolase 2 (Usp2); Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 2 (Usp2); Usp2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-613, Full length protein
• Sequence: MSQLSSTLKRYTESSRYTDAPYAKPGYGTYTPSSYGANLAASFLEKEKLGFKPVSPTSFLPRPRTYGPSSILDCDRGRPLLRSDIIGSSKRSESQTRGNERPSGSGLNGGSGFSYGVSSNSLSYLPMNARDQGVTLSQKKSNSQSDLARDFSSLRTSDGYRTSEGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRKGSAPQVLTQAPPPSRVPEVLSPTYRPSGRYTLWEKSKGQASGPSRSSSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFMGYNQQDAQEFLRFLLDGLHNEVNRVAARPKASPETLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDILDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
• Sequence Length: 613

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 114052502
• NCBI GeneID: 53376
• NCBI Accession #: NP_058088.2
• NCBI GenBank Nucleotide #: NM_016808.2
• UniProt Accession #: O88623; Q6X4T9; Q6X4U1; Q8VD74; Q9JJ87
• Molecular Weight: 44,908 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 2 isoform Usp2-69
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 2
• NCBI Official Symbol: Usp2
• NCBI Official Synonym Symbols: Ubp41; B930035K21Rik
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 2
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 2
• Protein Family: Protein
• UniProt Gene Name: Usp2
• UniProt Synonym Gene Names: Ubp41

Uniprot Description

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (). Has no deubiquitinase activity against p53/TP53 (). Prevents MDM2-mediated degradation of MDM4 (). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (PubMed:23213472, PubMed:25238854, PubMed:26756164). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (PubMed:25238854).