Mouse ubiquitin specific peptidase 2 ELISA Kit | USP2 elisa kit
Mouse Ubiquitin carboxyl-terminal hydrolase 2, USP2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
USP2: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Homooligomer. Found in trimeric complex with MDM2 and MDM4 and UPB2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C- terminus) with MDM2. Interacts with MDM4. Down-regulated by cisplatin. Expressed in mesangial cells of the kidney and in different types of glomerulonephritides. Cleavage is inhibited by ubiquitin in a dosage- dependent manner. Cleavage is blocked by ubiquitin aldehyde. Belongs to the peptidase C19 family. USP2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.19.12; Ubiquitin-specific protease; Protease
Cellular Component: perinuclear region of cytoplasm; cytoplasm; cell cortex; nucleus
Molecular Function: peptidase activity; identical protein binding; hydrolase activity; metal ion binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; cysteine-type peptidase activity
Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; locomotor rhythm; muscle development; protein deubiquitination; regulation of transcription, DNA-dependent; rhythmic process; circadian regulation of gene expression; proteolysis; cell cycle; circadian behavior; entrainment of circadian clock by photoperiod
Research Articles on USP2
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Product Notes
The Mouse USP2 usp2 (Catalog #AAA9333707) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333707 ELISA Kit recognizes Mouse USP2. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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