Regulator of nonsense transcripts 2 (UPF2) Recombinant Protein | UPF2 recombinant protein

Recombinant Human Regulator of nonsense transcripts 2 (UPF2) , partial

• Gene Names: UPF2; HUPF2; RENT2; smg-3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Regulator of nonsense transcripts 2 (UPF2); Recombinant Human Regulator of nonsense transcripts 2 (UPF2); partial; UPF2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 579

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for UPF2 recombinant protein

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

NCBI and Uniprot Product Information

• NCBI GI #: 11693132
• NCBI GeneID: 26019
• NCBI Accession #: NP_056357.1
• NCBI GenBank Nucleotide #: NM_015542.3
• UniProt Accession #: Q9HAU5; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9NWL1; Q9P2D9; Q9Y4M9; A6NLJ5; D3DRS0
• Molecular Weight: 66,842 Da
• NCBI Official Full Name: regulator of nonsense transcripts 2
• NCBI Official Synonym Full Names: UPF2, regulator of nonsense mediated mRNA decay
• NCBI Official Symbol: UPF2
• NCBI Official Synonym Symbols: HUPF2; RENT2; smg-3
• NCBI Protein Information: regulator of nonsense transcripts 2
• UniProt Protein Name: Regulator of nonsense transcripts 2
• Protein Family: Regulator of nonsense transcripts
• UniProt Gene Name: UPF2
• UniProt Synonym Gene Names: KIAA1408; RENT2; hUpf2

NCBI Description

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.