NKG2D Ligand 1/NKG2DL/ULBP1 Recombinant Protein | NKG2DL/ULBP1 recombinant protein

Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1 Protein (C-6His)

Cat. Num. AAA2553016

• Gene Names: ULBP1; N2DL-1; RAET1I; NKG2DL1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: NKG2D Ligand 1/NKG2DL/ULBP1; Recombinant Human NKG2D Ligand 1/NKG2DL/ULBP1 Protein (C-6His); NKG2D ligand 1; N2DL-1; NKG2DL1; ALCAN-beta; Retinoic acid early transcript 1I; UL16-binding protein 1; ULBP1; NKG2DL/ULBP1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Gly26-Pro215
• Sequence Length: 64

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for NKG2DL/ULBP1 recombinant protein

ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. It can activate multiple signaling pathways in primary NK cells, gamma delta T cells, and CD8+ alpha beta T cells, resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart, brain, lung, liver, bone marrow and some tumor cells, T-cells, B-cells, As an unconventional member of the MHC class I family, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.

NCBI and Uniprot Product Information

• NCBI GI #: 952556270
• NCBI GeneID: 80329
• NCBI Accession #: NP_001304018.1
• NCBI GenBank Nucleotide #: NM_001317089.1
• UniProt Accession #: Q9BZM6; Q5VY81; Q8IZW3; Q8IZX6
• Molecular Weight: Molecular Mass: 23.3 kDa; Actual Protein Molecular Mass: 25-30 kDa
• NCBI Official Full Name: UL16-binding protein 1 isoform 2
• NCBI Official Synonym Full Names: UL16 binding protein 1
• NCBI Official Symbol: ULBP1
• NCBI Official Synonym Symbols: N2DL-1; RAET1I; NKG2DL1
• NCBI Protein Information: UL16-binding protein 1
• UniProt Protein Name: UL16-binding protein 1
• UniProt Gene Name: ULBP1
• UniProt Synonym Gene Names: N2DL1; RAET1I; N2DL-1; NKG2DL1

NCBI Description

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.