Virion host shutoff protein (UL41) Recombinant Protein | UL41 recombinant protein
Recombinant Human herpesvirus 2 Virion host shutoff protein (UL41)
NCBI and Uniprot Product Information
Uniprot Description
Minor structural protein that acts as an endoribonuclease during lytic infection. Degrades host mRNAs in the cytoplasm by cutting them at preferred sites, including some in regions of translation initiation. Together with inhibition of host splicing by ICP27, contributes to an overall decrease in host protein synthesis. Also, after the onset of viral transcription, accelerates the turnover of viral mRNA, thereby facilitating the sequential expression of different classes of viral genes. Binds translation initiation factors eIF4H, eIF4AI, and eIF4AII, thereby may interact directly with the translation initiation complex and thus digest specifically mRNAs. Also impedes antigen presentation by major histocompatibility complex class I and class II molecules, inhibits secretion of cytokines that would otherwise recruit lymphocytes and neutrophils cells to the site of infection and blocks the activation of dendritic cells. Impedes the alpha/beta interferon-mediated response to infection ().
Research Articles on UL41
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Product Notes
The UL41 ul41 (Catalog #AAA1163177) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-492, Full length protein. The amino acid sequence is listed below: MGLFGMMKFA QTHHLVKRRG LRAPEGYFTP IAVDLWNVMY TLVVKYQRRY PSYDREAITL HCLCSMLRVF TQKSLFPIFV TDRGVECTEP VVFGAKAILA RTTAQCRTDE EASDVDASPP PSPITDSRPS FAFSNMRRRG HAFAPGDRGT RAAGPGPAAP SGAPSKPALR LAHLFCIRVL RALGYAYINS GQLEADDACA NLYHTNTVAY VHTTDTDLLL MGCDIVLDIS TGYIPTIHCR DLLQYFKMSY PQFLALFVRC HTDLHPNNTY ASVEDVLREC HWTAPSRSQA RRAARRERAN SRSLESMPTL TAAPVGLETR ISWTEILAQQ IAGEDDYEED PPLQPPDVAG GPRDGARSSS SEILTPPELV QVPNAQRVAE HRGYVAGRRR HVIHDAPEAL DWLPDPMTIA ELVEHRYVKY VISLISPKER GPWTLLKRLP IYQDLRDEDL ARSIVTRHIT APDIADRFLA QLWAHAPPPA FYKDVLAKFW DE. It is sometimes possible for the material contained within the vial of "Virion host shutoff protein (UL41), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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