Mouse ubiquitin-like with PHD and ring finger domains 2 ELISA Kit | UHRF2 elisa kit
Mouse E3 ubiquitin-protein ligase UHRF2, UHRF2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
UHRF2: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to tumorigenesis. Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin conjugating system; Cell cycle regulation; Ubiquitin ligase; EC 6.3.2.-; EC 6.3.2.19
Cellular Component: nucleoplasm; nuclear heterochromatin; nucleus
Molecular Function: DNA binding; zinc ion binding; histone binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein autoubiquitination; protein ubiquitination; cell cycle; cell differentiation
Research Articles on UHRF2
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Product Notes
The Mouse UHRF2 uhrf2 (Catalog #AAA9334786) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334786 ELISA Kit recognizes Mouse UHRF2. It is sometimes possible for the material contained within the vial of "ubiquitin-like with PHD and ring finger domains 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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