Ubiquilin-2 (Ubqln2) Recombinant Protein | Ubqln2 recombinant protein

Recombinant Mouse Ubiquilin-2 (Ubqln2)

Cat. Num. AAA1457804

• Gene Names: Ubqln2; Dsk2; Chap1; Plic2; Plic-2; HRIHFB2157
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquilin-2 (Ubqln2); Recombinant Mouse Ubiquilin-2 (Ubqln2); Ubqln2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-638, Full length protein
• Sequence: AENGESSGPPRPSRGPAAAPGAASPPAEPKIIKVTVKTPKEKEEFAVPENSTVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLMQHGIHDGLTVHLVIKSQNRPQGQATTQPSTTAGTSTTTTTTTTAAAPAATTSSAPRSSSTPTTTNSSSFGLGSLSSLSNLGLNSPNFTELQNQMQQQLLASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFATVGSSSTSGEGTQPSRTENRDPLPNPWAPPPTTQTAATTTTTTTTSSGSGSGSSSSSTTAGNTMAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDMAAQMMLSSPLFTSNPQLQEQMRPQLPNFLQQMQNPETIAAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFAPGVGMGVLGTAITPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPASSPGSTGTGIPPATTVSSSAPTETISPTSESGPNQQFIQQMVQALTGGSPPQPPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS
• Sequence Length: 637

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ubqln2 recombinant protein

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

NCBI and Uniprot Product Information

• NCBI GI #: 34328236
• NCBI GeneID: 54609
• NCBI Accession #: NP_061268.2
• NCBI GenBank Nucleotide #: NM_018798.2
• UniProt Accession #: Q9QZM0; Q7TSJ8; Q8VDH9; B1AY62
• Molecular Weight: 67,351 Da
• NCBI Official Full Name: ubiquilin-2
• NCBI Official Synonym Full Names: ubiquilin 2
• NCBI Official Symbol: Ubqln2
• NCBI Official Synonym Symbols: Dsk2; Chap1; Plic2; Plic-2; HRIHFB2157
• NCBI Protein Information: ubiquilin-2
• UniProt Protein Name: Ubiquilin-2
• Protein Family: Ubiquilin
• UniProt Gene Name: Ubqln2
• UniProt Synonym Gene Names: Plic2; PLIC-2

Uniprot Description

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (). Links CD47 to vimentin-containing intermediate filaments of the cytoskeleton (PubMed:10549293).