Human ubiquitination factor E4B (UFD2 homolog, yeast) ELISA Kit | UBE4B elisa kit
Human Ubiquitin conjugation factor E4 B, UBE4B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
UBE4B: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. Belongs to the ubiquitin conjugation factor E4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 1p36.3
Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex
Molecular Function: enzyme binding; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; induction of apoptosis by granzyme; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to UV
Research Articles on UBE4B
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Product Notes
The Human UBE4B ube4b (Catalog #AAA9317582) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317582 ELISA Kit recognizes Human UBE4B. It is sometimes possible for the material contained within the vial of "ubiquitination factor E4B (UFD2 homolog, yeast), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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