Human ubiquitin protein ligase E3B ELISA Kit | UBE3B elisa kit
Human Ubiquitin-protein ligase E3B, UBE3B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
UBE3B: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: cytoplasm; nucleus
Molecular Function: ubiquitin-protein ligase activity; ligase activity
Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
Disease: Kaufman Oculocerebrofacial Syndrome
Research Articles on UBE3B
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Product Notes
The Human UBE3B ube3b (Catalog #AAA9328088) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328088 ELISA Kit recognizes Human UBE3B. It is sometimes possible for the material contained within the vial of "ubiquitin protein ligase E3B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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