Ubiquitin Conjugating Enzyme E2L 6 Recombinant Protein | UBE2L6 recombinant protein

Recombinant Human Ubiquitin Conjugating Enzyme E2L 6

Cat. Num. AAA142488

• Gene Names: UBE2L6; RIG-B; UBCH8
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Ubiquitin Conjugating Enzyme E2L 6; Recombinant Human Ubiquitin Conjugating Enzyme E2L 6; UBE2L6 Human; Ubiquitin Conjugating Enzyme E2L 6 Human Recombinant; RIG-B; UBCH8; MGC40331; UBE2L6; Ubiquitin/ISG15-conjugating enzyme E2 L6; Ubiquitin-protein ligase L6; Ubiquitin carrier protein L6; Retinoic acid-induced gene B protein; UBE2L6 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The protein contains 20mM Tris pH-8, 0.1mM PMSF, 1mM DTT, and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS
• Sequence Length: 153

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for UBE2L6 recombinant protein

Description: UBE2L6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-152 a.a.) & having a molecular mass of 21.7 kDa. The UBE2L6 is fused to a 36 amino acid His Tag at N-terminus and purified by standard chromatography techniques.

Introduction: UBE2L6 belongs to the E2 ubiquitin-conjugating enzyme family. UBE2L6 enzyme is very similar in its primary structure to the enzyme encoded by UBE2L3 gene. UBE2L6 catalyzes the covalent attachment of ubiquitin to other proteins. UBE2L6 functions in the e6/e6-ap-induced ubiquitination of p53/tp53.

Product Categories/Family for UBE2L6 recombinant protein

Enzymes; Ubiquitin Conjugating Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 4759282
• NCBI GeneID: 9246
• NCBI Accession #: NP_004214.1
• NCBI GenBank Nucleotide #: NM_004223.4
• UniProt Accession #: O14933; Q8N5D8; Q9UEZ0; A6NDM6; A8MY53
• Molecular Weight: 10,086 Da
• NCBI Official Full Name: ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1
• NCBI Official Synonym Full Names: ubiquitin-conjugating enzyme E2L 6
• NCBI Official Symbol: UBE2L6
• NCBI Official Synonym Symbols: RIG-B; UBCH8
• NCBI Protein Information: ubiquitin/ISG15-conjugating enzyme E2 L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; ubiquitin carrier protein L6; ubiquitin-protein ligase L6
• UniProt Protein Name: Ubiquitin/ISG15-conjugating enzyme E2 L6
• Protein Family: Ubiquitin/ISG15-conjugating enzyme
• UniProt Gene Name: UBE2L6
• UniProt Synonym Gene Names: UBCH8; RIG-B
• UniProt Entry Name: UB2L6_HUMAN

NCBI Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Description

UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: cytosol

Molecular Function: protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity

Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; protein modification process; negative regulation of interferon type I production