Human ubiquitin-like modifier activating enzyme 3 ELISA Kit | UBA3 elisa kit
Human NEDD8-activating enzyme E1 Catalytic subunit, UBA3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
UBA3: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase; Cell cycle regulation; Nuclear receptor co-regulator; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component: cytosol; nucleus
Molecular Function: NEDD8 activating enzyme activity; protein binding; acid-amino acid ligase activity; protein heterodimerization activity; ATP binding
Biological Process: protein neddylation; regulation of cell cycle; protein modification process; proteolysis; endomitotic cell cycle
Research Articles on UBA3
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Product Notes
The Human UBA3 uba3 (Catalog #AAA9318304) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318304 ELISA Kit recognizes Human UBA3. It is sometimes possible for the material contained within the vial of "ubiquitin-like modifier activating enzyme 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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