Rat twist homolog 2 (Drosophila) ELISA Kit | TWIST2 elisa kit
Rat Twist-related protein 2, TWIST2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
inhibits Myc-induced apoptosis; may play a role in negative regulation of osteoblast differentiation [RGD, Feb 2006]
Uniprot Description
TWIST2: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. Defects in TWIST2 are the cause of Setleis syndrome (SETLEISS). A focal facial dermal dysplasia characterized by distinctive bitemporal scar-like depressions resembling forceps marks, and additional facial features, including a coarse and leonine appearance, absent eyelashes on both lids or multiple rows on the upper lids, absent Meibomian glands, slanted eyebrows, chin clefting, and hypo- or hyperpigmentation of the skin. Histologically, the bitemporal lesion is an ectodermal dysplasia with near absence of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal process and the first branchial arch.
Cellular Component: transcription factor complex; cytoplasm; nucleus
Molecular Function: protein dimerization activity; protein domain specific binding; DNA binding; chromatin binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; osteoblast differentiation; negative regulation of cell proliferation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; embryonic cranial skeleton morphogenesis; negative regulation of tumor necrosis factor production; negative regulation of transcription, DNA-dependent; negative regulation of DNA binding; negative regulation of apoptosis
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Product Notes
The Rat TWIST2 twist2 (Catalog #AAA9327541) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327541 ELISA Kit recognizes Rat TWIST2. It is sometimes possible for the material contained within the vial of "twist homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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