Mouse transient receptor potential cation channel, subfamily V, member 4 ELISA Kit | TRPV4 elisa kit
Mouse Transient receptor potential Cation channel subfamily V member 4, TRPV4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation
Cellular Component: cortical actin cytoskeleton; focal adhesion; cell surface; cell; integral to membrane; cytosol; cilium; growth cone; adherens junction; membrane; cytoplasmic microtubule; lamellipodium; plasma membrane; cytoplasmic vesicle; cell junction; filopodium
Molecular Function: microtubule binding; calcium channel activity; ion channel activity; nucleotide binding; beta-tubulin binding; actin binding; protein kinase binding; actin filament binding; calmodulin binding; protein binding; protein kinase C binding; osmosensor activity; cation channel activity; SH2 domain binding; alpha-tubulin binding; ATP binding
Biological Process: intercellular junction assembly; hypotonic response; actin filament organization; response to osmotic stress; regulation of response to osmotic stress; cellular calcium ion homeostasis; osmosensory signaling pathway; vasopressin secretion; positive regulation of microtubule depolymerization; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; transport; calcium ion transport; actin cytoskeleton reorganization; ion transport; cortical microtubule organization and biogenesis; transmembrane transport; microtubule polymerization
Research Articles on TRPV4
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Product Notes
The Mouse TRPV4 trpv4 (Catalog #AAA9325844) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325844 ELISA Kit recognizes Mouse TRPV4. It is sometimes possible for the material contained within the vial of "transient receptor potential cation channel, subfamily V, member 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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