Tripartite motif-containing protein 71 (TRIM71) Recombinant Protein | TRIM71 recombinant protein

Recombinant Human Tripartite motif-containing protein 71 (TRIM71) , partial

• Gene Names: TRIM71; LIN41; LIN-41
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tripartite motif-containing protein 71 (TRIM71); Recombinant Human Tripartite motif-containing protein 71 (TRIM71); partial; TRIM71 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 868

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 84993742
• NCBI GeneID: 131405
• NCBI Accession #: NP_001034200.1
• NCBI GenBank Nucleotide #: NM_001039111.2
• UniProt Accession #: Q2Q1W2
• Molecular Weight: 93,385 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRIM71
• NCBI Official Synonym Full Names: tripartite motif containing 71
• NCBI Official Symbol: TRIM71
• NCBI Official Synonym Symbols: LIN41; LIN-41
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM71
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM71
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: TRIM71
• UniProt Synonym Gene Names: LIN41

NCBI Description

The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]

Uniprot Description

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233).