Mouse tripartite motif-containing 24 ELISA Kit | TRIM24 elisa kit
Mouse Transcription intermediary factor 1-alpha, TRIM24 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Uniprot Description
TRIM24: an atypical protein kinase that functions as a transcriptional coactivator. Originally identified as a mammalian protein that enhances the AF-2 activity of the retinoid X receptor (RXR) in a yeast genetic screen. Binds to nuclear receptors in an agonist and AF2-activating domain (AF2-AD) dependent manner. Binding to the agonist-nuclear receptor complex induces its own hyperphosphorylation as well as the phosphorylation of TFIIEa, TAFII28, and TAFII55. Belongs to a family of nuclear proteins that includes TIF1b and TIF1g. TIF1 proteins are characterized by an N-terminal region that contains a RING finger-B boxes-coiled coil (RBCC) motif, a poorly conserved central region, a C-terminal region that contains a PHD finger, and a bromodomain. Interacts with the heterochromatin-associated proteins HP1a, MOD1 (HP1b), and MOD2 (HP1g) and with the transcriptional repression domain KRAB, which is present in many Kruppel-type (C2H2) zinc finger proteins. May act as a repressor through the formation of transcriptionally inactive heterochromatin. Two splice variant isoforms have been described.
Protein type: Protein kinase, atypical; Transcription, coactivator/corepressor; EC 6.3.2.-; Nuclear receptor co-regulator; Kinase, protein; Tumor suppressor; Ubiquitin conjugating system; ATYPICAL group; TIF1 family
Cellular Component: nucleoplasm; perichromatin fibrils; cytoplasm; nucleolus; intracellular; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; zinc ion binding; p53 binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; transcription coactivator activity; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; estrogen response element binding; protein kinase activity; protein binding; DNA binding; sequence-specific DNA binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; chromatin binding; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: regulation of apoptosis; calcium ion homeostasis; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; regulation of protein stability; protein ubiquitination; protein catabolic process; negative regulation of transcription, DNA-dependent; protein amino acid phosphorylation
Research Articles on TRIM24
Similar Products
Product Notes
The Mouse TRIM24 trim24 (Catalog #AAA9320718) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320718 ELISA Kit recognizes Mouse TRIM24. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 24, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
